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RNA INTERFERENCE-MEDIATED KNOCKDOWN OF CD49E (α5 INTEGRIN CHAIN) IN HUMAN THYMIC EPITHELIAL CELLS MODULATES THE EXPRESSION OF MULTIPLE GENES AND DECREASES THYMOCYTE ADHESION
adesão de células heterocelulares
Timócitos
microambiente tímico
células T intratímicas
heterocellular cell adhesion
gene regulation
thymocytes
thymic microenvironment
cd49E
Author
Affilliation
Abstract
The thymus is a central lymphoid organ, in which bone marrow-derived T cell precursors undergo a complex process of maturation. Developing thymocytes interact with thymic microenvironment in a defined spatial order. A component of thymic microenvironment, the thymic epithelial cells, is crucial for the maturation of T-lymphocytes through cell-cell contact, cell matrix interactions and secretory of cytokines/chemokines. There is evidence that extracellular matrix molecules play a fundamental role in guiding differentiating thymocytes in both cortical and medullary regions of the thymic lobules. The interaction between the integrin α5β1 (CD49e/CD29; VLA-5) and fibronectin is relevant for thymocyte adhesion and migration within the thymic tissue. Our previous results have shown that adhesion of thymocytes to cultured TEC line is enhanced in the presence of fibronectin, and can be blocked with anti-VLA-5 antibody.
Keywords in Portuguese
Regulação gênicaadesão de células heterocelulares
Timócitos
microambiente tímico
células T intratímicas
Keywords
gene regulationheterocellular cell adhesion
gene regulation
thymocytes
thymic microenvironment
cd49E
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