| Author | Mariz, Fernanda Pinto | |
| Author | Carvalho, Luciana Rodrigues | |
| Author | Mello, Wallace de | |
| Author | Araújo, Alexandra de Queiroz Campos | |
| Author | Ribeiro, Márcia Gonçalves | |
| Author | Cunha, Maria do Carmo Soares Alves | |
| Author | Voit, Thomas | |
| Author | Butler-Browne, Gillian | |
| Author | Barbosa, Suse Dayse Silva | |
| Author | Savino, Wilson | |
| Access date | 2018-04-12T17:10:11Z | |
| Available date | 2018-04-12T17:10:11Z | |
| Document date | 2010 | |
| Citation | MARIZ, Fernanda Pinto; et al. Differential integrin expression by T lymphocytes: Potential role in DMD muscle damage. JOurnal of Neuroimmunology, v.223, p.128-130, 2010. | pt_BR |
| ISSN | 0165-5728 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25826 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Distrofia Muscular de Duchenne | pt_BR |
| Subject in Portuguese | Movimento Celular | pt_BR |
| Subject in Portuguese | Integrinas | pt_BR |
| Subject in Portuguese | Fibronectinas | pt_BR |
| Subject in Portuguese | Linfócitos T | pt_BR |
| Title | Differential integrin expression by T lymphocytes: potential role in DMD muscle damage | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jneuroim.2010.03.006 | |
| Abstract | The expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3(+)CD4(+) and CD3(+)CD8(+) defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4(+) and CD8(+) T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Traumatologia e Ortopedia. Centro de Pesquisa em Bioengenharia Ortopédica e Terapia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France. | pt_BR |
| Affilliation | Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Duchenne muscular dystrophy | pt_BR |
| Subject | T lymphocytes | pt_BR |
| Subject | Integrins | pt_BR |
| Subject | Fibronectin | pt_BR |
| Subject | Cell migration | pt_BR |
| e-ISSN | 1872-8421 | |
| Embargo date | 2030-01-01 | |
