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DIFFERENTIAL INTEGRIN EXPRESSION BY T LYMPHOCYTES: POTENTIAL ROLE IN DMD MUSCLE DAMAGE
Mariz, Fernanda Pinto et al. | Date Issued: 2010
Author
Mariz, Fernanda Pinto
Carvalho, Luciana Rodrigues
Mello, Wallace de
Araújo, Alexandra de Queiroz Campos
Ribeiro, Márcia Gonçalves
Cunha, Maria do Carmo Soares Alves
Voit, Thomas
Butler-Browne, Gillian
Barbosa, Suse Dayse Silva
Savino, Wilson
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil / Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Traumatologia e Ortopedia. Centro de Pesquisa em Bioengenharia Ortopédica e Terapia Celular. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Pediatria. Rio de Janeiro, RJ, Brasil.
Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
Université Pierre et Marie Curie-Paris. Institut de Myologie. Paris, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas sobre o Timo. Rio de Janeiro, RJ. Brasil.
Abstract
The expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3(+)CD4(+) and CD3(+)CD8(+) defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4(+) and CD8(+) T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients.
Keywords in Portuguese
Distrofia Muscular de Duchenne
Movimento Celular
Integrinas
Fibronectinas
Linfócitos T
 
Keywords
Duchenne muscular dystrophy
T lymphocytes
Integrins
Fibronectin
Cell migration
 
Publisher
Elsevier
Citation
MARIZ, Fernanda Pinto; et al. Differential integrin expression by T lymphocytes: Potential role in DMD muscle damage. JOurnal of Neuroimmunology, v.223, p.128-130, 2010.
DOI
10.1016/j.jneuroim.2010.03.006
ISSN
0165-5728