Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25841
Title: Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
Authors: Gopalan, Narendran
Andrade, Bruno de Bezerril
Swaminathan, Soumya
Affilliation: National Institute for Research in Tuberculosis. Mayor Sathyamoorthy. Road. Chetpet, Chennai, India
National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunology Section. Bethesda, MD, USA
National Institute for Research in Tuberculosis. Mayor Sathyamoorthy. Road. Chetpet, Chennai, India
Abstract: Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) is an exaggerated, dysregulated immune response against dead or viable antigens of Mycobacterium tuberculosis that frequently occurs after initiation of antiretroviral therapy despite an effective suppression of HIV viremia. Scientific advances in IRIS pathogenesis have led researchers and clinicians to postulate risk factors that could possibly predict this syndrome, in an attempt to reduce the incidence and the severity of IRIS, with appropriate anti-inflammatory therapy. This review is a summary of the available literature on pathogenic mechanisms involved from the macro to the micro level, the clinical spectrum, available predictors and the scope of these biomarkers to function as specific therapeutic targets, that could effectively modulate or ameliorate this syndrome in future.
Keywords: ART
Biomarkers for IRIS
HAART
HIV
IRIS
Paradoxical reaction
TB
keywords: Biomarcadores para IRIS
HIV
IRIS
Tuberculose
Mycobacterium tuberculosis
Issue Date: 2014
Publisher: Taylor & Francis
Citation: GOPALAN, N.; ANDRADE, B. B.; SWAMINATHAN, S. Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction. Expert Review of Clinical Immunology, v. 10, n. 5, p. 631-645, 2014.
Description: Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
DOI: 10.1586/1744666X.2014.892828
ISSN: 1744-666X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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