Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25852
Title: Haplotype frequencies based on eight polymorphic sites at the 3' untranslated region of the HLA-G gene in individuals from two different geographical regions of Brazil
Authors: Lucena-Silva, N.
Monteiro, A. R.
Albuquerque, R. S. de
Gomes, R. G.
Mendes-Junior, C. T.
Castelli, E. C.
Donadi, E. A.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunoparasitologia. Recife, PE, Brasil / IMIP Hospital. Pediatric Oncology Department. Molecular Biology Laboratory. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunoparasitologia. Recife, PE, Brasil / IMIP Hospital. Pediatric Oncology Department. Molecular Biology Laboratory. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunoparasitologia. Recife, PE, Brasil / University of São Paulo. School of Medicine of Ribeirão Preto. Department of Medicine. Division of Clinical Immunology. Ribeirão Preto, São Paulo, Brazil / University of São Paulo. School of Medicine of Ribeirão Preto. Department of Genetics. Ribeirão Preto, São Paulo, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Laboratório de Imunoparasitologia. Recife, PE, Brasil.
University of São Paulo. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Química. Ribeirão Preto, São Paulo, Brazil.
Federal University of Goiás – UFG. Biological Science Institute. Department of General Biology. Molecular Genetics and Cytogenetics Laboratory. Goiânia, GO, Brazil.
University of São Paulo. School of Medicine of Ribeirão Preto. Department of Medicine. Division of Clinical Immunology. Ribeirão Preto, São Paulo, Brazil.
Abstract: The Brazilian population represents an admixture of native Amerindians, Portuguese settlers and Africans who were brought as slaves during the colonization period that began in the 16th century and was followed by waves of immigrations of Europeans and Asians in the 20th century. The contribution of these different ethnic groups to the constitution of Brazilian populations from different geographic regions is variable and, in addition to environmental factors, might act by determining different allele profiles among Brazilian populations from different regions. We studied polymorphic sites at the 3' untranslated region of the HLA-G gene in individuals from a Northeastern Brazilian region and compared them to our previously published data about a Southeastern Brazilian region, located at a distance of 2589 km. Our results showed that most polymorphic sites present a similar distribution in both populations, except for the lower frequency of the +3003C allele in the Northeastern population compared to the Southeastern population. Although differences in genotypic distribution were only significant for the +3003 locus (P = 0.0201), the diversity of haplotypes was distinct for each population. These results are important for case-control studies on the association of human leucocyte antigen-G polymorphism with disease and also in terms of the genetic structure of two distinct Brazilian populations.
Keywords: Brazilian population
Human leucocyte antigen‐G
Polymorphism
3′ Untranslated region
keywords: População brasileira
Antígeno leucocitário humano ‐ G
polimorfismo
3′ Região não traduzida
DeCS: 3 'Regiões não traduzidas / genética
Variação antigênica / genética
Brasil
Antígenos HLA-G / genética
Haplótipos
Humanos
Polimorfismo Genético
Issue Date: 2012
Citation: LUCENA-SILVA, N. et al. Haplotype frequencies based on eight polymorphic sites at the 3’ untranslated region of the HLA-G gene in individuals from two different geographical regions of Brazil. Tissue Antigens, v. 79, n. 4, p. 272–278, abr. 2012.
DOI: 10.1111/j.1399-0039.2012.01842.x
ISSN: 1399-0039
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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