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DISTINCT INFLAMMATORY PROFILE UNDERLIES PATHOLOGICAL INCREASES IN CREATININE LEVELS ASSOCIATED WITH PLASMODIUM VIVAX MALARIA CLINICAL SEVERITY
Cruz, Luís Antonio Bahiana et al. | Date Issued: 2018
Author
Cruz, Luís Antonio Bahiana
Barral Netto, Manoel
Andrade, Bruno de Bezerril
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring. Translational and Epidemiological Research Initiative. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring. Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities, Salvador, BA, Brasil
Abstract
Although Plasmodium vivax infection is a frequent cause of malaria worldwide, severe presentations have been more regularly described only in recent years. In this setting, despite clinical descriptions of multi-organ involvement, data associating it with kidney dysfunction are relatively scarce. Here, renal dysfunction is retrospectively analyzed in a large cohort of vivax malaria patients with an attempt to dissect its association with disease severity and mortality, and to determine the role of inflammation in its progression.
Keywords in Portuguese
Malária
Plasmodium vivax
Creatinina
Mortalidade
Humanos
 
Keywords
Malária
Plasmodium vivax
Creatinine
Mortality
Humans
 
Publisher
Public Library of Science
Citation
CRUZ, L. A. B.; BARRAL NETTO, M.; ANDRADE, B. B. Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity. PLoS Neglected Tropical Diseases, v. 12, n. 3), e0006306, 2018.
DOI
10.1371/journal.pntd.0006306
ISSN
PLoS Neglected Tropical Diseases