Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25925
Title: Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity
Authors: Cruz, Luís Antonio Bahiana
Barral Netto, Manoel
Andrade, Bruno de Bezerril
Affilliation: Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring. Translational and Epidemiological Research Initiative. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring. Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities, Salvador, BA, Brasil
Abstract: Although Plasmodium vivax infection is a frequent cause of malaria worldwide, severe presentations have been more regularly described only in recent years. In this setting, despite clinical descriptions of multi-organ involvement, data associating it with kidney dysfunction are relatively scarce. Here, renal dysfunction is retrospectively analyzed in a large cohort of vivax malaria patients with an attempt to dissect its association with disease severity and mortality, and to determine the role of inflammation in its progression.
Keywords: Malária
Plasmodium vivax
Creatinine
Mortality
Humans
keywords: Malária
Plasmodium vivax
Creatinina
Mortalidade
Humanos
Issue Date: 2018
Publisher: Public Library of Science
Citation: CRUZ, L. A. B.; BARRAL NETTO, M.; ANDRADE, B. B. Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity. PLoS Neglected Tropical Diseases, v. 12, n. 3), e0006306, 2018.
DOI: 10.1371/journal.pntd.0006306
ISSN: PLoS Neglected Tropical Diseases
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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