| Author | Costa, Maria Fernanda Lima | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Torres, Karen Cecília de Lima | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Oliveira, Cesar de | |
| Author | Santos, Eduardo Tarazona | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2018-04-18T13:21:31Z | |
| Available date | 2018-04-18T13:21:31Z | |
| Document date | 2017 | |
| Citation | COSTA, Maria Fernanda Lima et al. Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. Exp Gerontol., v. 98, p. 47-53, 2017 | pt_BR |
| ISSN | 0531-5565 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25927 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Marcadores Inflamatórios | pt_BR |
| Subject in Portuguese | Interleucina-6 | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Quimiocinas | pt_BR |
| Title | Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.exger.2017.08.002 | |
| Abstract | Inflammation, particularly elevated IL-6 serum levels, has been associated with increased mortality risk, mostly in Caucasians. The influence of genetic ethno-racial background on this association is unknown. We examined associations between baseline serum levels of Interleukin-6 (IL-6) and other cytokines (IL1-2, TNF, IL-10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) with 15-year mortality in 1,191 admixed Brazilians aged 60 years and over. Elevated IL6 level (but not other biomarkers) was associated with increased risk of deaths with fully adjusted hazard ratios of 1.51 (95% CI = 1.15, 1.97), 1.54 (95% CI = 1.20, 1.96) and 1.79 (95% CI = 1.40, 2.29) for the 2nd, 3rd and the highest quartiles, respectively. Genomic African and Native American proportions did not modify the association (p > 0.05). The discriminatory ability to predict death of a model based on IL-6 alone was similar as that of a comprehensive morbidity score (C statistics = 0.59 and 0.60, respectively). The abilities of IL-6 and the morbidity score models to predict death remained stable for very long term after the baseline measurement. Our results indicate that genome-based African and Native American ancestries have no impact on the prognostic value of IL-6 for mortality. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Department of Epidemiology & Public Health. University College London. London, UK | pt_BR |
| Affilliation | Department of Epidemiology & Public Health. University College London. London, UK | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil | pt_BR |
| Subject | Inflammatory markers | pt_BR |
| Subject | Interleukin-6 | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Chemokines | pt_BR |
| Subject | Mortality | pt_BR |
| Subject | Genomic ancestry | pt_BR |
| Subject | Admixed population | pt_BR |
| Embargo date | 2022-01-01 | |
