Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25927
Title: Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging.
Authors: Costa, Maria Fernanda Lima
Mambrini, Juliana Vaz de Melo
Torres, Karen Cecília de Lima
Peixoto, Sérgio William Viana
Oliveira, Cesar de
Santos, Eduardo Tarazona
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Affilliation: Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil
Department of Epidemiology & Public Health. University College London. London, UK
Department of Epidemiology & Public Health. University College London. London, UK
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brazil
Abstract: Inflammation, particularly elevated IL-6 serum levels, has been associated with increased mortality risk, mostly in Caucasians. The influence of genetic ethno-racial background on this association is unknown. We examined associations between baseline serum levels of Interleukin-6 (IL-6) and other cytokines (IL1-2, TNF, IL-10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) with 15-year mortality in 1,191 admixed Brazilians aged 60 years and over. Elevated IL6 level (but not other biomarkers) was associated with increased risk of deaths with fully adjusted hazard ratios of 1.51 (95% CI = 1.15, 1.97), 1.54 (95% CI = 1.20, 1.96) and 1.79 (95% CI = 1.40, 2.29) for the 2nd, 3rd and the highest quartiles, respectively. Genomic African and Native American proportions did not modify the association (p > 0.05). The discriminatory ability to predict death of a model based on IL-6 alone was similar as that of a comprehensive morbidity score (C statistics = 0.59 and 0.60, respectively). The abilities of IL-6 and the morbidity score models to predict death remained stable for very long term after the baseline measurement. Our results indicate that genome-based African and Native American ancestries have no impact on the prognostic value of IL-6 for mortality.
Keywords: Inflammatory markers
Interleukin-6
Cytokines
Chemokines
Mortality
Genomic ancestry
Admixed population
keywords: Marcadores Inflamatórios
Interleucina-6
Citocinas
Quimiocinas
Issue Date: 2017
Publisher: Elsevier
Citation: COSTA, Maria Fernanda Lima et al. Predictive value of multiple cytokines and chemokines for mortality in an admixed population: 15-year follow-up of the Bambui-Epigen (Brazil) cohort study of aging. Exp Gerontol., v. 98, p. 47-53, 2017
DOI: 10.1016/j.exger.2017.08.002
ISSN: 0531-5565
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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