| Author | Jaeger, Lauren Hubert | |
| Author | Brandão, Adeilton | |
| Access date | 2018-04-19T12:53:27Z | |
| Available date | 2018-04-19T12:53:27Z | |
| Document date | 2011 | |
| Citation | JAEGER, Lauren Hübert; BRANDÂO, Adeilton. The composition of upstream open reading frames (uORF) in four genes from Trypanosoma cruzi typical strains. Parasitol Res, v.109, p.1205–1208, 2011. | pt_BR |
| ISSN | 0932-0113 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/25942 | |
| Language | eng | pt_BR |
| Publisher | Springer Verlag (Germany) | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Trypanosoma cruzi | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Fases de Leitura Aberta | pt_BR |
| Subject in Portuguese | quatro genes | pt_BR |
| Title | The composition of upstream open reading frames (uORF) in four genes from Trypanosoma cruzi typical strains | pt_BR |
| Type | Article | |
| DOI | 10.1007/s00436-011-2430-4 | |
| Abstract | Upstream open reading frames (uORF) are small open reading frames located in the 5' untranslated region (5' utr) of a mature mRNA. We analysed in four strains representing the Trypanosoma cruzi groups Tc I, Tc II, Tc IV and Tc VI the uORF present in 5' utr sequences of four genes: P-type H+-ATPase 1, DEAD/H RNA helicase, casein kinase 1.1 and ferredoxin-NADP+ reductase. A segment in the 5' utr at each of these genes encompassing one or more uORF was PCR amplified and sequenced. An analysis of these sequences reveals that the uORF in T. cruzi show minor variations; however, these nucleotide substitutions mirror the divergence of T. cruzi strains into major groups. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | Trypanosoma cruzi | pt_BR |
| Subject | Chagas Disease | pt_BR |
| Subject | Upstream open reading frames | pt_BR |
| Subject | four genes | pt_BR |
| e-ISSN | 1432-1955 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
