Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/25942
Title: The composition of upstream open reading frames (uORF) in four genes from Trypanosoma cruzi typical strains
Authors: Jaeger, Lauren Hubert
Brandão, Adeilton
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.
Abstract: Upstream open reading frames (uORF) are small open reading frames located in the 5' untranslated region (5' utr) of a mature mRNA. We analysed in four strains representing the Trypanosoma cruzi groups Tc I, Tc II, Tc IV and Tc VI the uORF present in 5' utr sequences of four genes: P-type H+-ATPase 1, DEAD/H RNA helicase, casein kinase 1.1 and ferredoxin-NADP+ reductase. A segment in the 5' utr at each of these genes encompassing one or more uORF was PCR amplified and sequenced. An analysis of these sequences reveals that the uORF in T. cruzi show minor variations; however, these nucleotide substitutions mirror the divergence of T. cruzi strains into major groups.
Keywords: Trypanosoma cruzi
Chagas Disease
Upstream open reading frames
four genes
keywords: Trypanosoma cruzi
Doença de Chagas
Fases de Leitura Aberta
quatro genes
Issue Date: 2011
Publisher: Springer Verlag (Germany)
Citation: JAEGER, Lauren Hübert; BRANDÂO, Adeilton. The composition of upstream open reading frames (uORF) in four genes from Trypanosoma cruzi typical strains. Parasitol Res, v.109, p.1205–1208, 2011.
DOI: 10.1007/s00436-011-2430-4
ISSN: 0932-0113
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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