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https://www.arca.fiocruz.br/handle/icict/25976
INSULIN-LIKE GROWTH FACTOR II MESSENGER RNA-BINDING PROTEIN 3 IN SALIVARY GLAND TUMORS
Tumor maligno
Câncer salivar
Imuno-histoquímica
Author
Affilliation
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
A.C. Camargo Center Cancer, São Paulo, SP, Brasil
A.C. Camargo Center Cancer, São Paulo, SP, Brasil
Federal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
A.C. Camargo Center Cancer, São Paulo, SP, Brasil
A.C. Camargo Center Cancer, São Paulo, SP, Brasil
Federal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Dentistry and Health Post Graduation Program. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry, and Human Pathology Postgraduation Program. Laboratory of Oral Surgical Pathology.Salvador, BA, Brasil
Abstract
Insulin-like growth factor II mRNA-binding protein 3
(IMP3) is strongly expressed in malignant tumors and has been
associated with their aggressive behavior. The aim of this study
was to evaluate the presence of IMP3 in a series of salivary gland
tumors. The sample consisted of 9 pleomorphic adenomas (PA),
14 adenoid cystic carcinomas (ACC), and 13 mucoepidermoid
carcinomas (MEC) that were investigated by immunohistochemical
technique. All cases of PA and MEC were positive for
IMP3 particularly in the cytoplasm. PA showed 4 cases as high
expression and 6 as low expression. MEC showed 10 cases as
low expression and 3 as high expression. For ACC, 4 cases were
high expression, whereas 6 cases were low expression. No significant
difference was observed between tumors (P>0.05,
Fisher’s test) when both scores of IMP3 were compared. This
study showed that MEC seems to be more sensitive to IMP3
than ACC and provided an insight into this protein in salivary
gland tumors. Furthermore, although IMP3 is not a specific
diagnostic marker to distinguish the tumors studied, it seems to
mediate cell adhesion and migration in these tumors. Further
studies should be performed to better understand the IMP3
biology in salivary gland tumors.
Keywords in Portuguese
Fator de crescimento semelhante a insulina IITumor maligno
Câncer salivar
Imuno-histoquímica
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