Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
Metadata
Show full item record
IMPACT OF BACILLE CALMETTE-GUÉRIN REVACCINATION ON SERUM IGE LEVELS IN A RANDOMIZED CONTROLLED TRIAL
Author
Affilliation
Abstract
Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. Methods: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by
IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers
participating in a randomized controlled trial. Results: Serum total or Derp-specific IgE levels did not change regardless of the
increase in IFN-γ levels. Conclusions: BCG responsiveness does not affect protection against atopy.
Share