| Author | Costa, Maria Fernanda Lima | |
| Author | Mambrini, Juliana Vaz de Melo | |
| Author | Torres, Karen Cecília de Lima | |
| Author | Peixoto, Sérgio William Viana | |
| Author | Andrade, Fabíola Bof de | |
| Author | Oliveira, Cesar de | |
| Author | Santos, Eduardo Tarazona | |
| Author | Carvalho, Andrea Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Access date | 2018-04-25T14:14:58Z | |
| Available date | 2018-04-25T14:14:58Z | |
| Document date | 2017 | |
| Citation | COSTA, Maria Fernanda Lima et al. Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: The Bambui-Epigen Study. Archives of Gerontology and Geriatrics, v. 72, p. 103-107, 2017. | pt_BR |
| ISSN | 0167-4943 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26090 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | inflamação | pt_BR |
| Subject in Portuguese | Atividades Cotidianas | pt_BR |
| Title | Multiple inflammatory markers and 15-year incident ADL disability in admixed older adults: The Bambui-Epigen Study | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.archger.2017.05.013 | |
| Abstract | Background: The ability of inflammatory markers to predict disability in later life has received growing attention. However, the current evidence came predominantly from Caucasians and the role of genomic ancestry has not been investigated.
Objective: We investigated the prognostic value of multiple citokynes and chemokines for incident disability in admixed older Brazilians and whether genomic African and Native American ancestry affects the association.
Design: Population-based longitudinal study.
Setting: The Bambui-Epigen (Brazil) Cohort Study of Aging.
Subjects: 1171 males and females aged ≥60 years over 15-year of follow-up.
Methods: Outcome examined was incident activity of daily living (ADL) disability assessed annually (10,039 measures were performed). Serum levels of citokynes (IL6, IL12, TNF, IL10, and IL1β) and chemokines (CCL2, CCL5, CXCL8, CXCL9 and CXCL10) were measured at baseline. We used 370,539 Single Nucleotide Polymorphisms (SNPs) to estimate each individual genomic ancestry proportions. Potential confounding variables included a wide range of socio-demographic variables and health indicators. Statistical analyses were based on competing risk framework.
Results: The incidence rate of disability was 57.9 per 1000 person-years. IL6 level at the highest quartile showed an independent association with ADL disability (SRH = 1.32; 95% CI: 1.03, 1.70). Other inflammatory markers showed no statistically significant associations with the outcome. Neither genomic African nor Native American ancestry had an effect modifier on the associations (P for interaction >0.05 for all).
Conclusion: Among multi-inflammatory markers, only IL6 had the potential to identify people at increased risk of ADL disability, independently of ethno-racial background. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Enfermagem. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | University College London. Department of Epidemiology & Public Health. London, UK. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Activity of daily living | pt_BR |
| Subject | Genomic african ancestry | pt_BR |
| Subject | Ageing | pt_BR |
| Subject | Disability | pt_BR |
| Subject | Interleukin | pt_BR |
| Embargo date | 2022-01-01 | |
