| Author | Vieira, Debora Ferreira Barreto | |
| Author | Schatzmayr, Hermann Gonçalves | |
| Author | Takiya, Christina Maeda | |
| Author | Jácome, Fernanda Cunha | |
| Author | Silva, Manoel Enderson Vieira | |
| Author | Faria, Nieli Rodrigues da Costa | |
| Author | Nogueira, Rita Maria Ribeiro | |
| Author | Barth, Ortrud Monika | |
| Access date | 2018-04-26T10:59:30Z | |
| Available date | 2018-04-26T10:59:30Z | |
| Document date | 2010 | |
| Citation | VIEIRA, Debora Ferreira Barreto; et al. Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2. Virus Review and Research, v.15, n.2, 27p, 2010. | pt_BR |
| ISSN | 1519-2563 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26115 | |
| Language | eng | pt_BR |
| Publisher | Sociedade Brasileira de Virologia | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Dengue Virus-Tipo 2 | pt_BR |
| Subject in Portuguese | Dengue Virus Tipo1 | pt_BR |
| Subject in Portuguese | Fígado | pt_BR |
| Subject in Portuguese | Ultraestrutura | pt_BR |
| Subject in Portuguese | Histopatololgia | pt_BR |
| Subject in Portuguese | Camundongos Endogâmicos BALB C | pt_BR |
| Title | Morphological studies of hepatic tissue of mice reinfected with dengue virus serotypes 1 or 2 | pt_BR |
| Type | Article | |
| Abstract | Histopathological and ultrastructural aspects of liver of non-neuroadapted
BALB/c mice reinfected by the intravenous route with dengue virus serotypes 1 and 2
were presented. The hepatic tissue was processed following the standard techniques for
photonic and transmission electron microscopy. Morphological studies showed
vacuolization of hepatocytes, inflammatory cells inside sinusoidal capillaries,
enlargement of sinusoidal capillaries, foci of hemorrhage inside the interstitium,
increase of surface density of reticular fibres, increase of numerical density of
sinusoidal cells, decrease of surface density of hepatocytes, edema in the peri
centrolobular vein space and presence of phyllopods and pseudopod-like extensions in
endothelial cells. DENV particles, virus antigens and DENV RNA were observed in
mosquito cells (C6/36) inoculated with sera of the animals 72 hours post-reinfection.
The hepatic alterations observed in our experimental model were similar to those
observed in human cases of dengue hemorrhagic fever. The present study shows that
BALB/c mice reinfected with a heterologous serotype of DENV develop more severe
lesions than those observed in mice in primary infection. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Morfologia e Morfogênese Viral. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | dengue-2 virus | pt_BR |
| Subject | dengue-1 virus | pt_BR |
| Subject | BALB/c mice | pt_BR |
| Subject | liver | pt_BR |
| Subject | ultrastructure | pt_BR |
| Subject | histopathology | pt_BR |
| e-ISSN | 2357-9323 | |
