Author | Morais, Clarice Neuenschwander Lins de | |
Author | Carvalho, Bruno de Melo | |
Author | Melo, Wlademir Gomes de | |
Author | Melo, Fábio Lopes de | |
Author | Lopes, Edmundo Pessoa de Almeida | |
Author | Domingues, Ana Lúcia Coutinho | |
Author | Jucá, Norma | |
Author | Martins, João Roberto Maciel | |
Author | Diniz, George Tadeu Nunes | |
Author | Montenegro, Silvia Maria Lucena | |
Access date | 2018-04-26T12:03:44Z | |
Available date | 2018-04-26T12:03:44Z | |
Document date | 2010 | |
Citation | MORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010. | pt_BR |
ISSN | 1678-8060 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26119 | |
Sponsorship | PAPES V/FIOCRUZ, CNPq (to SMLM) | pt_BR |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Marcadores biológicos | pt_BR |
Subject in Portuguese | Fibrose hepática | pt_BR |
Subject in Portuguese | HC | pt_BR |
Subject in Portuguese | Esquistossomose | pt_BR |
Title | Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/S0074-02762010000400018 | |
Abstract | Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-gamma, TNF-alpha and TGF-beta, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, gamma-glutamil transferase (gamma-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-alpha (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), gamma-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de Pernambuco. Recife, PE, Brasil. | pt_BR |
Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil. | pt_BR |
Subject | Biological markers | pt_BR |
Subject | Hepatic fibrosis | pt_BR |
Subject | HC | pt_BR |
Subject | Schistosomiasis | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Análise de variação | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Biomarcadores / sangue | pt_BR |
DeCS | Estudos de caso-controle | pt_BR |
DeCS | Hepatite C / sangue | pt_BR |
DeCS | Hepatite C / complicações | pt_BR |
DeCS | Hepatite C / patologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Cirrose Hepática / sangue | pt_BR |
DeCS | Cirrose Hepática / complicações | pt_BR |
DeCS | Cirrose hepática / patologia | pt_BR |
DeCS | Hepatopatias Parasitárias / sangue | pt_BR |
DeCS | Hepatopatias Parasitárias / complicações | pt_BR |
DeCS | Hepatopatias Parasitárias / patologia | pt_BR |
DeCS | Meia idade | pt_BR |
DeCS | Necrose / patologia | pt_BR |
DeCS | Curva ROC | pt_BR |
DeCS | Esquistossomose / sangue | pt_BR |
DeCS | Esquistossomose / complicações | pt_BR |
DeCS | Esquistossomose / patologia | pt_BR |
DeCS | Índice de Gravidade da Doença | pt_BR |
DeCS | Doenças esplênicas / sangue | pt_BR |
DeCS | Doenças esplênicas / complicações | pt_BR |
DeCS | Doenças esplênicas / patologia | pt_BR |
DeCS | Adulto jovem | pt_BR |