Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26119
Title: Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients
Authors: Morais, Clarice Neuenschwander Lins de
Carvalho, Bruno de Melo
Melo, Wlademir Gomes de
Melo, Fábio Lopes de
Lopes, Edmundo Pessoa de Almeida
Domingues, Ana Lúcia Coutinho
Jucá, Norma
Martins, João Roberto Maciel
Diniz, George Tadeu Nunes
Montenegro, Silvia Maria Lucena
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Recife, PE, Brasil.
Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Abstract: Liver biopsy is the gold-standard method to stage fibrosis; however, it is an invasive procedure and is potentially dangerous. The main objective of this study was to evaluate biological markers, such as cytokines IL-13, IFN-gamma, TNF-alpha and TGF-beta, platelets, bilirubins (Bil), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), total proteins, gamma-glutamil transferase (gamma-GT) and alkaline phosphatase (AP), that could be used to predict the severity of hepatic fibrosis in schistosomiasis and hepatitis C (HC) as isolated diseases or co-infections. The following patient groups were selected: HC (n = 39), HC/hepatosplenic schistosomiasis (HSS) (n = 19), HSS (n = 22) and a control group (n = 13). ANOVA and ROC curves were used for statistical analysis. P < 0.05 was considered significant. With HC patients we showed that TNF-alpha (p = 0.020) and AP (p = 0.005) could differentiate mild and severe fibrosis. With regard to necroinflammatory activity, AST (p = 0.002), gamma-GT (p = 0.034) and AP (p = 0.001) were the best markers to differentiate mild and severe activity. In HC + HSS patients, total Bil (p = 0.008) was capable of differentiating between mild and severe fibrosis. In conclusion, our study was able to suggest biological markers that are non-invasive candidates to evaluate fibrosis and necroinflammatory activity in HC and HC + HSS.
Keywords: Biological markers
Hepatic fibrosis
HC
Schistosomiasis
keywords: Marcadores biológicos
Fibrose hepática
HC
Esquistossomose
DeCS: Adolescente
Adulto
Análise de variação
Idoso
Biomarcadores / sangue
Estudos de caso-controle
Hepatite C / sangue
Hepatite C / complicações
Hepatite C / patologia
Humanos
Cirrose Hepática / sangue
Cirrose Hepática / complicações
Cirrose hepática / patologia
Hepatopatias Parasitárias / sangue
Hepatopatias Parasitárias / complicações
Hepatopatias Parasitárias / patologia
Meia idade
Necrose / patologia
Curva ROC
Esquistossomose / sangue
Esquistossomose / complicações
Esquistossomose / patologia
Índice de Gravidade da Doença
Doenças esplênicas / sangue
Doenças esplênicas / complicações
Doenças esplênicas / patologia
Adulto jovem
Issue Date: 2010
Citation: MORAIS, C. N. L. DE et al. Correlation of biological serum markers with the degree of hepatic fibrosis and necroinflammatory activity in hepatitis C and schistosomiasis patients. Memorias Do Instituto Oswaldo Cruz, v. 105, n. 4, p. 460–466, jul. 2010.
DOI: 10.1590/S0074-02762010000400018
ISSN: 1678-8060
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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