Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2615
Title: Transmission of Streptococcus pneumoniae in an Urban Slum Community
Authors: Reis, Joice Neves
Palma, Tania
Ribeiro, Guilherme de Sousa
Pinheiro, Ricardo M.
Ribeiro, Cássio Tâmara
Cordeiro, Soraia Machado
Silva Filho, Hermes Pedreira da
Moschioni, Monica
Thompson, Terry A
Spratt, Brian G
Riley, Lee Woodland
Barocchi, Michele A
Reis, Mitermayer Galvão dos
Ko, Albert Icksang
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Novartis Vaccines. Siena, Italia
Centers for Disease Control and Prevention. Streptococcus Laboratory. Atlanta, United States of America
Imperial College. Department of Infectious Disease Epidemiology. London, UK
School of Public Health, University of Califórnia. Division of Infectious Diseases. Berkeley, CA, United States of America
Novartis Vaccines. Siena, Italia
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5-18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2-6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis.The study's findings indicate that there is significant intra- and inter-household spread of S. pneumoniae in the slum community setting. However, a limited number of clones encountered during carriage among slum residents were found to cause invasive disease.
Keywords: Streptococcus pneumoniae
Nasopharyngeal Carriage
pneumococcal conjugate vaccines
Antibiotic Resistance
Urban Slums
DeCS: Streptococcus pneumoniae
Vacinas Pneumocócicas
Portador Sadio
Técnica de Tipagem Bacteriana
DNA Bacteriano
Farmacorresistência Bacteriana
Vacinas Meningocócicas
Áreas de Pobreza
Issue Date: 2008
Citation: REIS, J. N. et al. Transmission of Streptococcus pneumoniae in an Urban Slum Community. Journal of Infection, v.57, n.3, p. 204-213, Sept. 2008.
DOI: 10.1016/j.jinf.2008.06.017
ISSN: 0163-4453
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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