Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26167
Title: Increased levels of IgA antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi differentiate digestive forms of Chagas disease
Authors: Vasconcelos, Romero H. T.
Amaral, Fábio N.
Cavalcanti, Maria G. A. M.
Silva, Edimilson D.
Ferreira, Antonio G. P.
Morais, Clarice N. L.
Gomes, Yara M.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Universidade de Pernambuco. Hospital Universitário Oswaldo Cruz. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Departamento de Reativos para Diagnóstico. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Bio-Manguinhos. Departamento de Reativos para Diagnóstico. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Recife, PE, Brasil.
Abstract: In the chronic phase of Chagas disease, individuals infected by Trypanosoma cruzi may be asymptomatic or may present cardiac and/or digestive complications. Our aim here was to analyze the relationship between the presence of specific immunoglobulin A antibodies and the different chronic clinical forms of Chagas disease using two recombinant antigens of Trypanosoma cruzi, cytoplasmatic repetitive antigen and flagellar repetitive antigen. The association of this immunoglobulin isotype with the digestive and cardio-digestive forms of the disease determined by indirect enzyme-linked immunosorbent assay, strongly suggests that IgA antibodies against these recombinant antigens of T. cruzi can be used as an immunological marker of the digestive alterations caused by Chagas disease. The tests performed in this study show that it is possible to differentiate digestive forms of Chagas disease. The knowledge provided by these results may help physicians to manage early alterations in the digestive tract of patients with the indeterminate or cardiac forms of Chagas disease. Prospective studies, however, with follow-up of the patients that presenting with high levels of immunoglobulin A against cytoplasmatic repetitive antigen and flagellar repetitive antigen recombinant antigens, need to be conducted to confirm this hypothesis.
Keywords: Immunoglobulin A.
Recombinant antigens
Trypanosoma cruzi
Chagas disease
Biologic markers
keywords: Imunoglobulina A
Antígenos Recombinantes
Trypanosoma cruzi
Doença de Chagas
Marcadores biológicos
DeCS: Adulto
Idoso
Antígenos, Protozoários / imunologia
Antígenos, protozoários / metabolismo
Biomarcadores / sangue
Doença de Chagas / sangue
Doença de Chagas / diagnóstico
Doença de Chagas / imunologia
Doença de Chagas / fisiopatologia
Doença crônica
Diagnóstico Diferencial
Doenças do Sistema Digestivo
Progressão da doença
Ensaio de Imunoadsorção Enzimática
Fêmea
Humanos
Imunoglobulina A / sangue
Masculino
Meia idade
Proteínas Protozoárias / imunologia
Proteínas Protozoárias / metabolismo
Proteínas Recombinantes / metabolismo
Trypanosoma cruzi / imunologia
Trypanosoma cruzi / patogenicidade
Issue Date: 2010
Publisher: Elsevier
Citation: VASCONCELOS, R. H. T. et al. Increased levels of IgA antibodies against CRA and FRA recombinant antigens of Trypanosoma cruzi differentiate digestive forms of Chagas disease. Human Immunology, v. 71, n. 10, p. 964–967, out. 2010.
DOI: 10.1016/j.humimm.2010.07.004
ISSN: 20659514
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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