Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26272
Title: Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil
Authors: Braga, Cynthia
Luna, Carlos Feitosa
Martelli, Celina Mariaturchi
Souza, Wayner Vieira de
Cordeiro, Marli Tenório
Alexander, Neal
Albuquerque, Maria de Fátima Pessoa Militão de
Silveira Júnior, José Constantino
Marques, Ernesto T.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Instituto de Medicina Integral Professor Fernando Figueira – IMIP. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Universidade Federal de Goias. Instituto de Patologia Tropical e Saúde Publica. Departamento de Saúde Coletiva. Goiania, GO, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Secretaria de Saude do Estado de Pernambuco. Laboratorio Central de Saude Publica. Recife, PE, Brazil.
London School of Hygiene and Tropical Medicine. Infectious Diseases Epidemiology Unit Keppel. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil / The Johns Hopkins School of Medicine, Division of Infectious Diseases. Baltimore, Maryland, USA.
Abstract: Brazil currently accounts for the majority of dengue cases reported in the Americas, with co-circulation of DENV 1-3. Striking variation in the epidemiological pattern of infection within cities has been observed. Therefore, investigation of dengue transmission in small areas is important to formulate control strategies. A population-based household survey was performed in three diverse socio-economic and environmental areas of Recife, a large urban center of Brazil, between 2005 and 2006. Dengue serostatus and individual- and household-level risk factors for infection were collected in residents aged between 5 and 64 years. A total of 2833 individuals were examined, and their residences were geo-referenced. Anti-dengue IgG antibodies were measured using commercial ELISA. The dengue seroprevalence and the force of infection were estimated in each area. Individual and household variables associated with seropositivity were assessed by multilevel models for each area. A spatial analysis was conducted to identify risk gradients of dengue seropositivity using Generalized Additive Models (GAM). The dengue seroprevalence was 91.1%, 87.4% 74.3%, respectively, in the deprived, intermediate and high socio-economic areas, inversely related to their socio-economic status. In the deprived area, 59% of children had already been exposed to dengue virus by the age of 5 years and the estimated force of infection was three times higher than that in the privileged area. The risk of infection increased with age in the three areas. Not commuting away from the area was a risk factor for seropositivity in the deprived area (OR=2.26; 95% CI: 1.18-4.30). Number of persons per room was a risk factor for seropositivity in the intermediate (OR=3.00; 95% CI: 3.21-7.37) and privileged areas (OR=1.81; 95% CI: 1.07-3.04). Living in a house, as opposed to an apartment, was a risk factor for seropositivity in the privileged area (OR=3.62; 95% CI: 2.43-5.41). The main difference between the privileged and other areas could be attributed to the much larger proportion of apartment dwellers. Intensive vector control, surveillance and community education should be considered in deprived urban areas where a high proportion of children are infected by an early age.
Keywords: Dengue
Seroprevalence
Risk factors
Spatial analysis
keywords: Dengue
Soroprevalência
Fatores de risco
Análise espacial
DeCS: Adolescente
Adulto
Anticorpos virais / sangue
Brasil / epidemiologia
Criança
Criança, pré-escolar
Dengue / epidemiologia
Vírus da Dengue / imunologia
Ensaio de Imunoadsorção Enzimática / métodos
Fêmea
Humanos
Imunoglobulina G / sangue
Masculino
Meia idade
Fatores de risco
Estudos soroepidemiológicos
Fatores Socioeconômicos
População urbana
Adulto jovem
Issue Date: 2010
Publisher: Elsevier
Citation: BRAGA, C. et al. Seroprevalence and risk factors for dengue infection in socio-economically distinct areas of Recife, Brazil. Acta Tropica, v. 113, n. 3, p. 234–240, mar. 2010.
DOI: 10.1016/j.actatropica.2009.10.021
ISSN: 1873-6254
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos



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