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2021-01-01
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CULEX QUINQUEFASCIATUS MOSQUITOES DO NOT SUPPORT REPLICATION OF ZIKA VIRUS
Oliveira, Ricardo Lourenço de et al. | Date Issued: 2018
Author
Oliveira, Ricardo Lourenço de
Marques, João T.
Sreenu, Vattipally B.
Nten, Célestine Atyame
Aguiar, Eric Roberto Guimarães Rocha
Varjak, Margus
Kohl, Alain
Failloux, Anna-Bella
Affilliation
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors. Paris, France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.
MRC-University of Glasgow. Centre for Virus Research. Glasgow G61 1QH, Scotland, UK.
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors. Paris, France.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.
MRC-University of Glasgow. Centre for Virus Research. Glasgow G61 1QH, Scotland, UK.
MRC-University of Glasgow. Centre for Virus Research. Glasgow G61 1QH, Scotland, UK.
Institut Pasteur. Department of Virology, Arboviruses and Insect Vectors. Paris, France.
Abstract
The rapid spread of Zika virus (ZIKV) in the Americas raised many questions about the role of Culex quinquefasciatus mosquitoes in transmission, in addition to the key role played by the vector Aedes aegypti. Here we analysed the competence of Cx. quinquefasciatus (with or without Wolbachia endosymbionts) for a ZIKV isolate. We also examined the induction of RNA interference pathways after viral challenge and the production of small virus-derived RNAs. We did not observe any infection nor such small virus-derived RNAs, regardless of the presence or absence of Wolbachia. Thus, Cx. quinquefasciatus does not support ZIKV replication and Wolbachia is not involved in producing this phenotype. In short, these mosquitoes are very unlikely to play a role in transmission of ZIKV.
Keywords in Portuguese
Zika virus
Américas
Culex quinquefasciatus
 
Keywords
Culex quinquefasciatus
Zika virus
Americas
 
Publisher
Microbiology Society
Citation
OLIVEIRA, Ricardo Lourenço de; et al. Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, v. 99, p. 258-264, 2018.
DOI
10.1099/jgv.0.000949
ISSN
0022-1317