Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26285
Title: RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
Authors: Oliveira, Camila
Faoro, Helisson
Alves, Lysangela Ronalte
Goldenberg, Samuel
Affilliation: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Abstract: RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model organism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast.
Keywords: RNA-Binding Proteins
Gene Expression Regulation
Keywords in spanish: Proteínas de Unión al ARN
Regulación de la Expresión Génica
keywords: Trypanosoma cruzi
Saccharomyces cerevisiae
DeCS: Proteínas de Ligação a RNA
Regulação da Expressão Gênica
Issue Date: 2017
Publisher: Sociedade Brasileira de Genética
Citation: OLIVEIRA, Camila et al. RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae. Genetics and Molecular Biology, v. 40, n. 1, p. 22-30, 2017.
DOI: 10.1590/1678-4685-GMB-2016-0258
ISSN: 1678-4685
Copyright: open access
Appears in Collections:PR - ICC - Artigos de Periódicos

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