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2030-01-01
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- IOC - Artigos de Periódicos [12969]
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LIDOCAINE-DERIVATIVE JMF2-1 PREVENTS OVALBUMIN-INDUCED AIRWAY INFLAMMATION BY REGULATING THE FUNCTION AND SURVIVAL OF T CELLS
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Abstract
Inhalation of the local anaesthetic lidocaine has been suggested to be beneficial for asthmatics, but airway anaesthesia is unpleasant and may exacerbate bronchoconstriction. Our previous study showed that inhalation of the lidocaine analogue JMF2-1 can elicit the anti-inflammatory properties of lidocaine without anaesthesia. This prompted further research on the mechanism of action and putative therapeutic application of JMF2-1.
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