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2030-01-01
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- INI - Artigos de Periódicos [3033]
- IOC - Artigos de Periódicos [12119]
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AMERICAN TEGUMENTARY LEISHMANIASIS IN OLDER ADULTS: 44 CASES TREATED WITH AN INTERMITTENT LOW-DOSE ANTIMONIAL SCHEDULE IN RIO DE JANEIRO, BRAZIL
Adultos Idosos
Antimoniato de meglumina em baixa dose
Rio de Janeiro
Older adults
Low-dose meglumine antimonate
Rio de Janeiro
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Abstract
American tegumentary leishmaniasis (ATL) is a disease affecting the skin and mucosae caused by protozoans of the genus Leishmania transmitted by the bite of female sandflies. Cutaneous leishmaniasis (CL) presents mainly as skin ulcers at exposed body sites. Mucosal leishmaniasis (ML) manifests as chronic and destructive lesions of the nasal, oral, pharyngeal, and laryngeal tissues.1 Pentavalent antimonials are the first-line treatment for ATL. Reports of pentavalent antimonial toxicity include renal tubular dysfunction; cardiac, hepatic, pancreatic, and hematological alterations; and even death.2–6 Adverse effects (AEs) are frequent, and interruption is sometimes needed in patients aged 60 and older, even those receiving
low-dose treatment. Observing that lesions continued to heal during withdrawal, it was decided to evaluate the safety and efficacy of an intermittent low-dose meglumine antimonate (MA) regimen for ATL in the elderly.
Keywords in Portuguese
Leishmaniose tegumentar americanaAdultos Idosos
Antimoniato de meglumina em baixa dose
Rio de Janeiro
Keywords
American tegumentary leishmaniasisOlder adults
Low-dose meglumine antimonate
Rio de Janeiro
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