| Author | Moreira, Marcela de Lima | |
| Author | Tsuji, Moriya | |
| Author | Corbett, Alexandra Jane | |
| Author | Araújo, Márcio Sobreira Silva | |
| Author | Carvalho, Andréa Teixeira de | |
| Author | Martins Filho, Olindo Assis | |
| Author | Pascoal, Vanessa Peruhype Magalhães | |
| Author | Reis, Jordana Grazziela Alves Coelho dos | |
| Access date | 2018-05-14T16:25:45Z | |
| Available date | 2018-05-14T16:25:45Z | |
| Document date | 2017 | |
| Citation | MOREIRA, Marcela de Lima et al. MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases? Immunology Letters, v. 187, p. 53-60, 2017. | pt_BR |
| ISSN | 0165-2478 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26426 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | MAIT-celulas | pt_BR |
| Subject in Portuguese | MR1 | pt_BR |
| Subject in Portuguese | TCRVα7.2 | pt_BR |
| Subject in Portuguese | CD161 I | pt_BR |
| Title | MAIT-cells: A tailor-made mate in the ancient battle against infectious diseases? | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.imlet.2017.05.007 | |
| Abstract | It has been almost two decades since the discovery of mucosal-associated invariant T (MAIT)-cells. Several advances in the field have been made such as the discovery of the antimicrobial activity of MAIT-cells, the abundance of these cells in human mucosa and in liver and the discovery of ligands able to bind MR1 and activate MAIT-cells. MAIT-cells are a unique subset of innate-like T-cells that express a canonical T-cell receptor with the alpha chain containing hAV7S2 and AJ33 in humans (TCRVα7.2Jα33) and respond to bacterial/fungus vitamin B2 metabolites by an MR1-dependent pathway. Indirect activation is also observed during chronic viral infections by and IL-12/IL-18 pathway. In this review, the mechanisms of activation, the timeline of MAIT-cell development in humans as well as their role in human infection are discussed. On the whole, we believe that harnessing the anti-microbial ability of MAIT-cells could contribute for the design of potent immunotherapies and vaccines against “hard-to-kill” infectious agents that remain as public health threats worldwide. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Aaron Diamond AIDS Research Center. The Rockefeller University, New York, NY, USA. | pt_BR |
| Affilliation | Department of Microbiology and Immunology. Peter Doherty Institute for Infection and Immunity. University of Melbourne. Melbourne, Australia. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | MAIT-cells | pt_BR |
| Subject | MR1 | pt_BR |
| Subject | TCRVα7.2 | pt_BR |
| Subject | TRAV1-2 | pt_BR |
| Subject | CD161 | pt_BR |
| Subject | Infectious diseases | pt_BR |
| Embargo date | 2023-01-01 | |
