Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26439
Title: Immunopathological studies of Leishmania amazonensis infection in resistant and in susceptible mice
Authors: Cardoso, Flávia de Oliveira
Souza, Celeste da Silva Freitas de
Mendes, Verônica Gonçalves
Silva, Ana Lúcia Abreu
Costa, Sylvio Celso Gonçalves da
Calabrese, Kátia da Silva
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Saúde Escola Germano Sinval Faria. Laboratório de Diagnóstico, Ensino e Pesquisa. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Experimentação Animal. Rio de Janeiro, RJ, Brasil.
Universidade Estadual do Maranhão. Departamento de Patologia. São Luis, MA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ. Brasil.
Abstract: Leishmania amazonensis infection was studied in mice to evaluate the evolution of leishmaniasis. The association of different methods, such as lesion kinetics, limiting dilution analysis, and immunohistochemistry, established different levels of susceptibility and resistance. Mice were arranged in 3 groups: susceptible (C57BL/10 and CBA), relatively resistant (DBA/2), and resistant (C3H.He). The histopathological analysis of primary lesions and draining lymph nodes showed a predominance of eosinophils and mast cells in the initial phase of infection in all mice. However, the most susceptible mice presented a greater number of amastigotes and higher tissue damage. The immunoglobulin analysis showed that susceptible mice produced high levels of antibodies, whereas resistant and relatively resistant mice exhibited low production of antibodies. Resistant mice showed parasite persistency in the skin and lymph nodes, suggesting that the infection in these mice can be sustained through the infection of cells such as dendritic cells, fibroblasts, and other cells present in these organs.
Keywords: Leishmania amazonensis
Infection
Immunopathological Studies
keywords: Leishmania amazonensis
Infecção
Estudos imunopatológicos
Issue Date: 2010
Publisher: Oxford University Press
Citation: CARDOSO, Flávia de Oliveira; et al. Immunopathological Studies of Leishmania amazonensis Infection in Resistant and in Susceptible Mice. The Joiurnal of Infectious Diseases, v.201, n.12, p.1933-1940, 2010.
DOI: 10.1086/652870
ISSN: 0022-1899
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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