| Author | Schreiber, Fernanda | |
| Author | Huo, Zhiming | |
| Author | Giemza, Rafaela | |
| Author | Woodrow, Maria | |
| Author | Fenner, Nicola | |
| Author | Stephens, Zoe | |
| Author | Dougan, Gordon | |
| Author | Prideaux, Steven | |
| Author | Branco, Luiz R. R. Castelo | |
| Author | Lewis, David J. M. | |
| Access date | 2018-05-17T15:09:47Z | |
| Available date | 2018-05-17T15:09:47Z | |
| Document date | 2010 | |
| Citation | SCHREIBER, Fernanda; et al. An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin. Vaccine, v.28, n.33, p.5427-5431, 2010. | pt_BR |
| ISSN | 0264-410X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26473 | |
| Language | eng | pt_BR |
| Publisher | Elsevier 12 Months | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | BCG | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | trato aerodigestivo | pt_BR |
| Subject in Portuguese | Imunidade inata | pt_BR |
| Subject in Portuguese | infecção | pt_BR |
| Subject in Portuguese | Mycobacterium bovis BCG | pt_BR |
| Title | An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.vaccine.2010.06.005 | |
| Abstract | Bacille Calmette Guérin substrain Moreau Rio de Janeiro is an attenuated strain of Mycobacterium bovis that has been used extensively as an oral tuberculosis vaccine. We assessed its potential as a challenge model to study clinical and immunological events following repeated mycobacterial gut infection. Seven individuals received three oral challenges with approximately 10(7) viable bacilli. Clinical symptoms, T-cell responses and gene expression patterns in peripheral blood were monitored. Clinical symptoms were relatively mild and declined following each oral challenge. Delayed T-cell responses were observed, and limited differential gene expression detected by microarrays. Oral challenge with BCG Moreau Rio de Janeiro vaccine was immunogenic in healthy volunteers, limiting its potential to explore clinical innate immune responses, but with low reactogenicity. | pt_BR |
| Affilliation | The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | St George’s University of London. St George’s Vaccine Institute. London, United Kingdom. | pt_BR |
| Subject | BCG | pt_BR |
| Subject | Oral challenge | pt_BR |
| Subject | Innate immunity | pt_BR |
| Subject | Mycobacterium bovis Bacille Calmette Guérin | pt_BR |
| e-ISSN | 1873-2518 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
