An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin

The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose. Rio de Janeiro, RJ, Brasil.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.

Abstract

Bacille Calmette Guérin substrain Moreau Rio de Janeiro is an attenuated strain of Mycobacterium bovis that has been used extensively as an oral tuberculosis vaccine. We assessed its potential as a challenge model to study clinical and immunological events following repeated mycobacterial gut infection. Seven individuals received three oral challenges with approximately 10(7) viable bacilli. Clinical symptoms, T-cell responses and gene expression patterns in peripheral blood were monitored. Clinical symptoms were relatively mild and declined following each oral challenge. Delayed T-cell responses were observed, and limited differential gene expression detected by microarrays. Oral challenge with BCG Moreau Rio de Janeiro vaccine was immunogenic in healthy volunteers, limiting its potential to explore clinical innate immune responses, but with low reactogenicity.

Keywords in Portuguese

BCG
Vacina
trato aerodigestivo
Imunidade inata
infecção
Mycobacterium bovis BCG

Keywords

BCG
Oral challenge
Innate immunity
Mycobacterium bovis Bacille Calmette Guérin

Publisher

Elsevier 12 Months

Citation

SCHREIBER, Fernanda; et al. An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin. Vaccine, v.28, n.33, p.5427-5431, 2010.

DOI

10.1016/j.vaccine.2010.06.005

ISSN

0264-410X

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26473

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Copyright

Restricted access

Embargo date

2030-01-01

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