Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26473

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2030-01-01
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AN INVESTIGATION OF CLINICAL AND IMMUNOLOGICAL EVENTS FOLLOWING REPEATED AERODIGESTIVE TRACT CHALLENGE INFECTIONS WITH LIVE MYCOBACTERIUM BOVIS BACILLE CALMETTE GUÉRIN
Schreiber, Fernanda et al. | Date Issued: 2010
Author
Schreiber, Fernanda
Huo, Zhiming
Giemza, Rafaela
Woodrow, Maria
Fenner, Nicola
Stephens, Zoe
Dougan, Gordon
Prideaux, Steven
Branco, Luiz R. R. Castelo
Lewis, David J. M.
Affilliation
The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
The Wellcome Trust Sanger Institute. The Wellcome Trust Genome Campus. Hinxton, United KIngdom.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose. Rio de Janeiro, RJ, Brasil.
St George’s University of London. St George’s Vaccine Institute. London, United Kingdom.
Abstract
Bacille Calmette Guérin substrain Moreau Rio de Janeiro is an attenuated strain of Mycobacterium bovis that has been used extensively as an oral tuberculosis vaccine. We assessed its potential as a challenge model to study clinical and immunological events following repeated mycobacterial gut infection. Seven individuals received three oral challenges with approximately 10(7) viable bacilli. Clinical symptoms, T-cell responses and gene expression patterns in peripheral blood were monitored. Clinical symptoms were relatively mild and declined following each oral challenge. Delayed T-cell responses were observed, and limited differential gene expression detected by microarrays. Oral challenge with BCG Moreau Rio de Janeiro vaccine was immunogenic in healthy volunteers, limiting its potential to explore clinical innate immune responses, but with low reactogenicity.
Keywords in Portuguese
BCG
Vacina
trato aerodigestivo
Imunidade inata
infecção
Mycobacterium bovis BCG
 
Keywords
BCG
Oral challenge
Innate immunity
Mycobacterium bovis Bacille Calmette Guérin
 
Publisher
Elsevier 12 Months
Citation
SCHREIBER, Fernanda; et al. An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin. Vaccine, v.28, n.33, p.5427-5431, 2010.
DOI
10.1016/j.vaccine.2010.06.005
ISSN
0264-410X