After the report of an outbreak of dengue virus serotype 2 in 2014 in Nampula and Pemba cities, northern Mozambique, a surveillance system was established by the National Institute of Health. A study was performed during 2015–2016 to monitor the trend of the outbreak and confirm the circulating serotype of dengue virus (DENV). After the inclusionofconsentingpatientswhometthecasedefinition,samplesfrom192patientsweretestedforthepresenceof nonstructuralprotein1antigen,and60/192(31%)sampleswerepositive.FurtheranalysisincludedDENVIgMantibodies, with39(20%)IgMpositivecases.Reversetranscriptase(RT)PCRwasperformedforidentificationoftheprevailingDENV serotype; 21/23 tested samples were DENV-2 positive, with DENV-2 present in both affected cities. When sequencing DENV, phenotype Cosmopolitan was identified. The surveillance indicates ongoing spread of DENV-2 in northern Mozambique 2 years after the first report of the outbreak.