Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/26891
Title: Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs
Authors: Araújo, Marina Rios de
Damasceno, Karine Araujo
Gamba, Conrado de Oliveira
Campos, Cecília Bonolo
Campos, Liliane Cunha
Reis, Diego Carlos dos
Souza, Cristina Maria de
Cassali, Geovanni Dantas
Affilliation: Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Sao Paulo State University. School of Agricultural and Veterinary Sciences. Postgraduate Program of Veterinary Medicine. Jaboticabal, SP, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Federal University of Minas Gerais. Institute of Biological Sciences. Comparative Pathology Laboratory. Belo Horizonte, MG, Brazil
Abstract: In bitches, mammary tumors represent 52% of all neoplasms. The phyllodes tumor is a rare fibro-epithelial neoplasm found in humans characterized by epithelial and mesenchymal (stromal) cell proliferation creating elaborate leaf-like structures. Morphological and immune-histochemical characteristics in 5 canine phyllodes tumors are described. Four benign and one malignant phyllodes tumors were diagnosed. Epithelial and stromal tumor cells were positive for cytokeratin AE1AE3 and vimentin, respectively, and all were positive for estrogen and progesterone receptors. Benign tumors were negative for p63 whereas the malignant tumor was positive for p63. Cell proliferation index was <1% in benign tumors tissue but 69.5% in the malignant one. All tumors were negative for c-KIT. The morphological and immune-phenotypical aspects observed in this study suggest similarities between phyllodes tumors diagnosed in women and in bitches. However, new studies are necessary to enhance knowledge regarding the biological behavior of these neoplasms.
Keywords: Dog
Immunohistochemistry
Mammary neoplasm
Phyllodes tumor
keywords: Cachorro
Imuno-histoquímica
Neoplasia mamária
Tumor phyllodes
Issue Date: 2014
Publisher: Desconhecida
Citation: ARAÚJO0, M. R. et al. Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs. Online Journal of Veterinary Research: OJVR, v. 18, n. 8, p. 688-695, 2014.
Description: Damasceno, Karine Araújo. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 1328-925X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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