Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27192
Title: Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?
Authors: Gomes, Yara M.
Lorena, Virginia M. B.
Luquetti, Alejandro O.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunoparasitologia. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunoparasitologia. Recife, PE, Brasil.
Universidade Federal de Goiás. Hospital das Clínicas. Goiânia, GO, Brasil.
Abstract: In the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission.
Keywords: Chagas disease
Trypanosoma cruzi
Etiological diagnosis
keywords: Doença de Chagas
Trypanosoma cruzi
Diagnóstico etiológico
DeCS: Doença Aguda
Anticorpos, protozoários / sangue
Doença de Chagas / diagnóstico
Doença de Chagas / quimioterapia
Doença crônica
Ensaio de Imunoadsorção Enzimática
Humanos
Imunoblotting
Reação em Cadeia da Polimerase
Sensibilidade e Especificidade
Testes Sorológicos
Tripanocidas Agentes / uso terapêutico
Trypanosoma cruzi / genética
Trypanosoma cruzi / imunologia
Issue Date: 2009
Citation: GOMES, Y. M.; LORENA, V. M. B.; LUQUETTI, A. O. Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? Memorias Do Instituto Oswaldo Cruz, v. 104 Suppl 1, p. 115–121, jul. 2009.
DOI: 10.1590/S0074-02762009000900017
ISSN: 1678-8060
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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