| Author | Almeida, Isabel Marlúcia Lopes Moreira de | |
| Author | Ramos, Carmen Viana | |
| Author | Rodrigues, Danielle Carvalho | |
| Author | Sousa, Amanda Carvalho de | |
| Author | Nascimento, Maria de Lourdes Cristina Alcântara Paz Carvalho do | |
| Author | Silva, Marcos Vilhena Bittencourt da | |
| Author | Batista, Francisca Miriane Araújo | |
| Author | Santos, Jéssica Pereira dos | |
| Author | Oliveira, Roselaine Sampaio | |
| Author | Nobre, Filipe Augusto de Freitas | |
| Author | Xavier, Samanta Cristina das Chagas | |
| Author | Carvalho-Costa, Filipe Anibal | |
| Access date | 2018-07-09T12:29:36Z | |
| Available date | 2018-07-09T12:29:36Z | |
| Document date | 2018 | |
| Citation | ALMEIDA, Isabel Marlúcia Lopes Moreira de et al. Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015–2016. Jornal de Pediatria, Rio de Janeiro, p. 1-9, 2018. | pt_BR |
| ISSN | 0021-7557 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27359 | |
| Language | eng | pt_BR |
| Rights | restricted access | |
| Title | Clinical and epidemiological aspects of microcephaly in the state of Piauí, northeastern Brazil, 2015-2016 | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.jped.2018.04.013 | pt_BR |
| Abstract | Objectives: To describe aspects of the microcephaly epidemic in the state of Piauí. Methods: All cases of congenital microcephaly confirmed in the state between 2015 and 2016 were included (n = 100). Investigation forms of the Regional Reference Center for Microcephaly were reviewed. Discarded cases (n = 63) were used as a comparison group. Results: In October, November, and December 2015 incidence rates reached 4.46, 6.33 and 3.86/1000 live births, respectively; 44 cases were reported in the state capital. Among the mothers of confirmed and discarded cases, the frequency of skin rash during pregnancy was 50/97 (51.5%) and 8/51 (15.7%), respectively (p < 0.001); 33 confirmed cases (35.9%) had a
head circumference z-score between −2 and −3, 23 (25%) between
−3 and −4, and 8 (8.7%) had a z-score of less than −4. Head computer tomography scans revealed calcifications in 78/95 (82.1%) cases. Lissencephaly, hydrocephalus and agenesis of the corpus callosum were
also frequently observed. Ophthalmic findings included retinal pigment epithelium rarefaction and atrophy. Absence of otoacoustic emissions was observed in 21/70 cases. One newborn also presented lower limb muscle atrophy. There were no significant differences in vaccination rates
for influenza, diphtheria-tetanus-acellular pertussis, and hepatitis B in either group. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Governo do Estado do Piauí. Centro Regional de Referência Regional em Microcefalia. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Piauí. Teresina, PI, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Escritório Regional Fiocruz Piauí. Teresina, PI, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Microcephaly | pt_BR |
| Subject | Infants | pt_BR |
| Subject | Zika | pt_BR |
| Subject | State of Piauí | pt_BR |
| Embargo date | 2022-07-09 | |
