Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2746
Title: Are there differences in clinical and laboratory parameters between children and adults with American visceral leishmaniasis?
Authors: Caldas, Arlene de Jesus Mendes
Costa, Jackson Mauricio Lopes
Aquino, Dorlene Maria Cardoso de
Silva, Antonio Augusto Moura da
Barral Netto, Manoel
Barral, Aldina Maria Prado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal do Maranhão. Departamento de Enfermagem. São Luís, MA, Brasil
Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, Brasil
Abstract: Aprospective study on 23 patients with American visceral leishmaniasis (VL), comparing clinical and laboratory parameters of 14 children (mean age of 3.85±3.39 years) to nine adults (27.4±10.90 years) was performed in S˜ao Lu´ıs, Maranh˜ao, Brazil, between August 2000 and July 2002. Data were collected at entrance (day 0), end of treatment, as well as 120 and 210 days after treatment using a protocol chart containing patient identification, clinical and laboratory data. N-Methylglucamine antimonate administered at the dose of 20 mg/Sb5+/kg/day for 20–30 days was successfully used in all patients. Patients were followed for 1 year after treatment, and no relapses were observed. A prolonged duration of the disease, lymphadenopathy and bleeding predominated in adult patients, while hepatomegaly and skin-mucosal pallor were more frequent in children. Disease was longer and more severe in adults than in children. Although both groups exhibited a trend toward normalization of hematological and biochemical parameters, more children returned sooner to normal values than adults. Difference in clinical or laboratory parameters between children and adults did not indicate the need for different clinical or therapeutic approaches.
Keywords: American Visceral Leishmaniasis
Children
Adults
Delayed-type Hypersensitivity
Lymphoproliferative Response
keywords: Leishmaniose Visceral Americana
Crianças
Adultos
Hipersensibilidade tardia
Resposta Linfoproliferativa
DeCS: Leishmaniose Visceral
Criança
Adulto
Hipersensibilidade Tardia
Issue Date: 2006
Citation: CALDAS, A. J. M. et al. Are there differences in clinical and laboratory parameters between children and adults with American visceral leishmaniasis? Acta Tropica, v.97, n.3, p.252-258, 2006.
DOI: 10.1016/j.actatropica.2005.09.010
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Caldas_Costa_Aquino_etal.pdf117.67 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.