Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27565
Title: Analysis of an acute Chagas disease outbreak in the Brazilian Amazon: human cases, triatomines, reservoir mammals and parasites
Authors: Valente, Sebastião Aldo da Silva
Valente, Vera da Costa
Pinto, Ana Yecê das Neves
César, Maria de Jesus Barbosa
Santos, Marivaldo Picanço dos
Miranda, Clóvis Omar Sá
Cuervo, Patrícia
Fernandes, Octavio
Affilliation: Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.
Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Belém, PA, Brasil.
Secretaria de Saúde do Estado do Amapá. Macapá, AP, Brasil.
Secretaria de Saúde do Estado do Amapá. Macapá, AP, Brasil.
Secretaria de Saúde do Estado do Amapá. Macapá, AP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Abstract: An outbreak of Chagas disease occurred in Mazagão, Amapá, Brazilian Amazon in 1996. Seventeen of 26 inhabitants presented symptoms compatible with acute Chagas disease and were submitted to parasitological and serological tests. All 17 were positive in at least one parasitological test and 11 were also IgM or IgG anti-Trypanosoma cruzi positive. The nine asymptomatic patients were negative for parasites and one was positive for IgG anti-T. cruzi. Sixty-eight triatomines were captured (66 Rhodnius pictipes; two Panstrongylus geniculatus); 45 were infected with T. cruzi (43 R. pictipes; two P. geniculatus). Thirteen trypanosomatid strains were isolated: eight from humans and five from R. pictipes. Four were genotyped as T. cruzi I (two from humans; two from R. pictipes), seven as T. cruzi Z3 (six from humans; one from R. pictipes) and two as T. cruzi Z3 and T. rangeli (from R. pictipes). Treatment started for all patients leading to a decrease in parasitaemia in 16 during the follow-up period (6 months, 1, 5 and 7 years). All were serologically negative 7 years post-treatment. There was an overlap of genotypes in the same ecotope, raising the possibility of transmission through the oral route and the need for early therapeutic intervention for better patient management in the Brazilian Amazon.
Keywords: Trypanosoma cruzi
Chagas Disease
Outbreak
oral transmission
Amazon
Brazil
keywords: Trypanosoma cruzi
Doença de Chagas
Surtos de Doenças
Transmissão oral
Amazônia
Brasil
Issue Date: 2009
Publisher: Elsevier
Citation: VALENTE, Sebastião Aldo da Silva; et al. Analysis of an acute Chagas disease outbreak in the Brazilian Amazon: human cases, triatomines, reservoir mammals and parasites. Transactions of the Royal Society of Tropical Medicine and Hygiene, v.103, p.291—297, 2009.
DOI: 10.1016/j.trstmh.2008.10.047
ISSN: 0035-9203
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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