Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27730
Title: Evaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis
Authors: Marques, Cláudia Diniz Lopes
Duarte, Ângela Luzia Branco Pinto
Lorena, Virginia Maria Barros de
Souza, Joelma Rodrigues
Souza, Wayner Vieira
Gomes, Yara de Miranda
Carvalho, Eduardo Maia Freese de
Affilliation: Escola Pernambucana de Medicina, FBV/IMIP. Recife, PE, Brazil.
Universidade Federal de Pernambuco (UFPE). Hospital das Clinicas. Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Abstract: The tuberculin skin test is not an ideal screening test for the patients with rheumatoid arthritis to identify cases of latent tuberculosis infection (LTBI) prior to the start of treatment with anti-TNFs, as it responds inadequately to late hypersensitivity, which is fundamental for producing a response to the inoculated antigen. Assays based on detection of the production of IFNγ in vitro by mononuclear peripheral cells stimulated by specific antigens are more specific than PPD in detecting LTBI. The aim of this study was to evaluate the performance of T-SPOT.TB in diagnosis of LTBI in patients with rheumatoid arthritis, comparing with the PPD. The specificity of the T-SPOT.TB varied from 87 to 90% and the negative-predictive value (NPV) from 94.4 to 100%. It can be concluded that the T-SPOT.TB showed high specificity and NPV, proving the capability of identifying false-negative cases of PPD, raising the level of safety for the use of anti-TNFs.
Keywords: Rheumatoid arthritis
Tuberculosis
Diagnosis
Interferon-gamma assay
keywords: Artrite Reumatóide
Diagnóstico
Tuberculose
ensaio Interferon-gamma
DeCS: Adulto
Antígenos Bacterianos / imunologia
Agentes Antirreumáticos / uso terapêutico
Artrite Reumatóide / complicações
Artrite Reumatóide / quimioterapia
Artrite Reumatóide / imunologia
Biomarcadores / análise
Brasil
Distribuição Qui-Quadrado
Ensaio de Imunoadsorção Enzimática
Reações negativas falsas
Fêmea
Humanos
Interferon-gama / secreção
Tuberculose latente / complicações
Tuberculose Latente / diagnóstico
Tuberculose Latente / imunologia
Tuberculose Latente / microbiologia
Masculino
Meia idade
Mycobacterium tuberculosis / imunologia
Valor Preditivo de Testes
Kits de Reagentes, Diagnóstico
Sensibilidade e Especificidade
Linfócitos T / imunologia
Linfócitos T / microbiologia
Teste de tuberculina
Fator de Necrose Tumoral alfa / antagonistas e inibidores
Fator de Necrose Tumoral alfa / metabolismo
Issue Date: 2009
Citation: MARQUES, C. D. L. et al. Evaluation of an interferon gamma assay in the diagnosis of latent tuberculosis infection in patients with rheumatoid arthritis. Rheumatology International, v. 30, n. 1, p. 57–62, nov. 2009.
DOI: 10.1007/s00296-009-0910-y
ISSN: 1437-160X
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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