| Author | Bottecchia, Marcelle | |
| Author | Ikuta, Nilo | |
| Author | Niel, Christian | |
| Author | Araujo, Natalia M. | |
| Author | O, Kycia M. R. | |
| Author | Gomes, Selma A. | |
| Access date | 2018-08-02T14:19:13Z | |
| Available date | 2018-08-02T14:19:13Z | |
| Document date | 2008 | |
| Citation | BOTTECCHIA, Marcelle; et al. Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. Journal of Gastroenterology and Hepatology, v. 23, p. 67–72, 2008. | pt_BR |
| ISSN | 0815-9319 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27793 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Virus da Hepatite B | pt_BR |
| Subject in Portuguese | terapia com lamivudina | pt_BR |
| Subject in Portuguese | Resistência a medicamentos | pt_BR |
| Subject in Portuguese | Mutações | pt_BR |
| Subject in Portuguese | Casos fatais | pt_BR |
| Subject in Portuguese | Polimerase | pt_BR |
| Title | Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case | pt_BR |
| Type | Article | |
| DOI | 10.1111/j.1440-1746.2007.05238.x | |
| Abstract | Resistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation. Here we investigated virological factors associated with hepatic failure in a 58-year-old male, chronically HBV-infected patient who died after 33 months of lamivudine therapy. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Luterana do Brasil. Laboratório de Diagnóstico Molecular. Canoas, RS, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil / Fundação Municipal de Saúde Petrópolis. Petrópolis, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Subject | hepatitis B virus | pt_BR |
| Subject | lamivudine therapy | pt_BR |
| Subject | Drug resistance | pt_BR |
| Subject | Mutations | pt_BR |
| Subject | Fatal case | pt_BR |
| Subject | polymerase | pt_BR |
| e-ISSN | 1440-1746 | |
| Embargo date | 2030-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
