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2030-01-01
Sustainable Development Goals
03 Saúde e Bem-Estar
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LAMIVUDINE RESISTANCE AND OTHER MUTATIONS IN THE POLYMERASE AND SURFACE ANTIGEN GENES OF HEPATITIS B VIRUS ASSOCIATED WITH A FATAL HEPATIC FAILURE CASE
Bottecchia, Marcelle et al. | Date Issued: 2008
Author
Bottecchia, Marcelle
Ikuta, Nilo
Niel, Christian
Araujo, Natalia M.
O, Kycia M. R.
Gomes, Selma A.
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Universidade Luterana do Brasil. Laboratório de Diagnóstico Molecular. Canoas, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil / Fundação Municipal de Saúde Petrópolis. Petrópolis, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ. Brasil.
Abstract
Resistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation. Here we investigated virological factors associated with hepatic failure in a 58-year-old male, chronically HBV-infected patient who died after 33 months of lamivudine therapy.
Keywords in Portuguese
Virus da Hepatite B
terapia com lamivudina
Resistência a medicamentos
Mutações
Casos fatais
Polimerase
 
Keywords
hepatitis B virus
lamivudine therapy
Drug resistance
Mutations
Fatal case
polymerase
 
Publisher
Wiley
Citation
BOTTECCHIA, Marcelle; et al. Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. Journal of Gastroenterology and Hepatology, v. 23, p. 67–72, 2008.
DOI
10.1111/j.1440-1746.2007.05238.x
ISSN
0815-9319