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Title: Population-based multicentric survey of hepatitis B infection and risk factor differences among three regions in Brazil
Authors: Pereira, Leila M. M. B.
Martelli, Celina M. T.
Merchán-Hamann, Edgar
Montarroyos, Ulisses R.
Braga, Maria C.
Lima, Maria L. C. de
Cardoso, Maria R. A.
Turchi, Marília D.
Costa, Marcelo A.
Alencar, Luiz C. A. de
Moreira, Regina C.
Figueiredo, Gerusa M.
Ximenes, Ricardo A. A.
Affilliation: Universidade de Pernambuco. Hospital Universitário Oswaldo Cruz. Faculdade de Ciências Médicas de Pernambuco. Recife, Pernambuco, Brazil.
Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Publica. Departamento de Saúde Coletiva. Goiania, Goiás, Brazil.
Universidade de Brasília. Faculdade de Ciências da Saúde. Departamento de Saúde Coletiva.Distrito Federal, Brasília, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Universidade Federal de Pernambuco. Departamento Medicina Social/Núcleo de Saúde Pública, e Departamento de Medicina Tropical. Recife, Pernambuco, Brazil.
Universidade de São Paulo. Faculdade de Saúde Publica. Departamento de Epidemiologia. São Paulo, SP, Brazil.
Hospital de Base do DF. Brasília, DF, Brazil.
Instituto Adolfo Lutz. São Paulo, SP, Brazil.
Ministério da Saúde. Programa Nacional de Prevenção e Controle das Hepatites Virais. Brasília, DF, Brazil.
Universidade de Pernambuco. Instituto do Fígado de Pernambuco. Recife, PE, Brazil.
Abstract: This multicentric population-based study in Brazil is the first national effort to estimate the prevalence of hepatitis B (HBV) and risk factors in the capital cities of the Northeast, Central-West, and Federal Districts (2004-2005). Random multistage cluster sampling was used to select persons 13-69 years of age. Markers for HBV were tested by enzyme-linked immunosorbent assay. The HBV genotypes were determined by sequencing hepatitis B surface antigen (HBsAg). Multivariate analyses and simple catalytic model were performed. Overall, 7,881 persons were included; < 70% were not vaccinated. Positivity for HBsAg was less than 1% among non-vaccinated persons and genotypes A, D, and F co-circulated. The incidence of infection increased with age with similar force of infection in all regions. Males and persons having initiated sexual activity were associated with HBV infection in the two settings; healthcare jobs and prior hospitalization were risk factors in the Federal District. Our survey classified these regions as areas with HBV endemicity and highlighted the risk factors differences among the settings.
DeCS: Adolescente
Brasil / epidemiologia
Estudos Transversais
Hepatite B / epidemiologia
Anticorpos Contra Hepatite B / sangue
Meia idade
Odds Ratio
Fatores de Risco
Características Sexuais
Fatores Socioeconômicos
Adulto jovem
Issue Date: 2009
Citation: PEREIRA, L. M. M. B. et al. Population-based multicentric survey of hepatitis B infection and risk factor differences among three regions in Brazil. The American Journal of Tropical Medicine and Hygiene, v. 81, n. 2, p. 240–247, ago. 2009.
ISSN: 1476-1645
Copyright: restricted access
Appears in Collections:PE - IAM - Artigos de Periódicos

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