Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2787
Title: High serum nitric oxide levels in patients with severe leptospirosis
Authors: Maciel, Elves Anderson Pires
Athanazio, Daniel Abensur
Reis, Eliana Almeida Gomes
Cunha, Fernando Queiroz
Queiroz, Adriano
Almeida, Deusdelia Teixeira de
McBride, Alan John Alexander
Ko, Albert Icksang
Reis, Mitermayer Galvão dos
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Weill Medical College of Cornell University. Division of International Medicine and Infectious Disease. New York, NY, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
Abstract: Leptospirosis is a globally distributed zoonosis of major public health importance and is associated with severe disease manifestations such as acute renal failure and pulmonary haemorrhage syndrome. However, the extent to which the pathogenesis of leptospirosis mimics sepsis caused by Gramnegative bacteria remains unknown. The aim of this study was to evaluate serum levels of nitric oxide (NO) in patients diagnosed with severe leptospirosis. Sera from 35 confirmed cases of severe leptospirosis and 13 healthy subjects were analysed. Patients with severe leptospirosis had significantly higher NO levels compared to healthy individuals (30.82 ± 10.90 μM versus 3.86 ± 1.34 μM, P<0.001), indicating that this immune mediator plays a role in the underlying systemic inflammatory response.
Keywords: Leptospirosis
Nitric Oxide
Acute renal failure
Pulmonary Haemorrhage
keywords: Leptospirose
Óxido Nítrico
Insuficiência Renal Aguda
Hemorragia Pulmonar
DeCS: Adolescente
Adulto
Idoso
Marcadores Biológicos
Brasil
Feminino
Febre
Humanos
Icterícia
Leptospirose
Masculino
Meia-Idade
Óxido Nítrico
Insuficiência Respiratória
Choque
Issue Date: 2006
Publisher: Elsevier
Citation: MACIEL, E. A. P. et al. High serum nitric oxide levels in patients with severe leptospirosis. Acta Tropica, v.100, n.3, p.256–260, dez. 2006.
ISSN: 0001-706X
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Maciel_Athanazio_Reis_etal.pdf138.77 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.