| Author | Araujo, Jacqueline | |
| Author | Segat, Ludovica | |
| Author | Guimarães, Rafael L. | |
| Author | Brandão, Lucas A. C. | |
| Author | Souza, Paulo E. R. | |
| Author | Santos, Sérgio | |
| Author | Soares, Thereza S. | |
| Author | Falcão, Elcy A. | |
| Author | Rodrigues, Fernanda | |
| Author | Carvalho, Ronaldo | |
| Author | Lima-Filho, José Luiz de | |
| Author | Arraes, Luiz Claudio | |
| Author | Crovella, Sergio | |
| Access date | 2018-08-07T11:44:23Z | |
| Available date | 2018-08-07T11:44:23Z | |
| Document date | 2009 | |
| Citation | ARAUJO, Jacqueline et al. Mannose Binding Lectin Gene Polymorphisms and Associated Auto-Immune Diseases in Type 1 Diabetes Brazilian Patients. Clinical Immunology (Orlando, Fla.), v. 131, n. 2, p. 254–259, maio 2009. | pt_BR |
| ISSN | 1521-7035 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/27964 | |
| Sponsorship | Este trabalho foi apoiado por uma bolsa da FACEPE (Recife, Brasil) (APQ-0131-4.01 / 07) e por uma bolsa do Ministério da Saúde italiano RC03 / 04. Lucas Brandão e Rafael Guimarães são bolsistas de doutorado da FACEPE (IBPG-0020-2.02 / 07; IBPG-0134-2.02 / 08). A Ludovica Segat recebeu uma bolsa de subsídio (APQ-0020-4.01 / 08) da FACEPE. | pt_BR |
| Language | eng | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | Lectina de ligação à manose | pt_BR |
| Subject in Portuguese | Polimorfismos | pt_BR |
| Subject in Portuguese | Diabetes Mellitus | pt_BR |
| Subject in Portuguese | Tipo 1 | pt_BR |
| Subject in Portuguese | Tireoidite | pt_BR |
| Subject in Portuguese | Autoimune | pt_BR |
| Subject in Portuguese | Doença celíaca | pt_BR |
| Title | Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients | pt_BR |
| Type | Article | |
| DOI | 10.1016/j.clim.2008.12.010 | |
| Abstract | In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC). Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease. Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D. | pt_BR |
| Affilliation | Federal University of Pernambuco. Pediatric Endocrinology Unit of Clinical Hospital. Recife, PE, Brazil / Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil. | pt_BR |
| Affilliation | University of Trieste. Genetic Service IRCCS Burlo Garofolo. Trieste, Italy / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Biologia celular e Ultraestrutura. Recife, PE, Brasil. | pt_BR |
| Affilliation | Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil. | pt_BR |
| Affilliation | Restoration Hospital. Recife, PE, Brasil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil. | pt_BR |
| Affilliation | Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil. | pt_BR |
| Affilliation | University of Trieste. Genetic Service IRCCS Burlo Garofolo. Trieste, Italy / Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil. | pt_BR |
| Subject | Mannose binding lectin | pt_BR |
| Subject | Polymorphisms | pt_BR |
| Subject | Diabetes mellitus | pt_BR |
| Subject | Type 1 | pt_BR |
| Subject | Thyroiditis | pt_BR |
| Subject | Autoimmune | pt_BR |
| Subject | Celiac disease | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Doenças Auto- Imunes / complicações | pt_BR |
| DeCS | Doenças Autoimunes / epidemiologia | pt_BR |
| DeCS | Doenças Auto- Imunes / genética | pt_BR |
| DeCS | Brasil / epidemiologia | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Criança, pré-escolar | pt_BR |
| DeCS | Diabetes Mellitus Tipo 1 / complicações | pt_BR |
| DeCS | Diabetes Mellitus, tipo 1 / epidemiologia | pt_BR |
| DeCS | Diabetes Mellitus, tipo 1 / genética | pt_BR |
| DeCS | Fêmea | pt_BR |
| DeCS | Predisposição Genética para Doença | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Infantil | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Manose - Encadernação Lectina / genética | pt_BR |
| DeCS | Polimorfismo de Nucleotídeo Único | pt_BR |
| DeCS | Padrões de referência | pt_BR |
| Embargo date | 2050-01-01 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
