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MANNOSE BINDING LECTIN GENE POLYMORPHISMS AND ASSOCIATED AUTO-IMMUNE DISEASES IN TYPE 1 DIABETES BRAZILIAN PATIENTS
Araujo, Jacqueline et al. | Date Issued: 2009
Author
Araujo, Jacqueline
Segat, Ludovica
Guimarães, Rafael L.
Brandão, Lucas A. C.
Souza, Paulo E. R.
Santos, Sérgio
Soares, Thereza S.
Falcão, Elcy A.
Rodrigues, Fernanda
Carvalho, Ronaldo
Lima-Filho, José Luiz de
Arraes, Luiz Claudio
Crovella, Sergio
Affilliation
Federal University of Pernambuco. Pediatric Endocrinology Unit of Clinical Hospital. Recife, PE, Brazil / Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil.
University of Trieste. Genetic Service IRCCS Burlo Garofolo. Trieste, Italy / Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Biologia celular e Ultraestrutura. Recife, PE, Brasil.
Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil.
Restoration Hospital. Recife, PE, Brasil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Federal University of Pernambuco. Laboratory of Immunopathology Keizo Asami (LIKA). Recife, PE, Brazil.
Fernando Figueira Maternal and Children's Institute. Recife, PE, Brazil.
University of Trieste. Genetic Service IRCCS Burlo Garofolo. Trieste, Italy / Federal University of Pernambuco. Department of Genetics. Recife, PE, Brazil.
Abstract
In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC). Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease. Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D.
Keywords in Portuguese
Lectina de ligação à manose
Polimorfismos
Diabetes Mellitus
Tipo 1
Tireoidite
Autoimune
Doença celíaca
 
Keywords
Mannose binding lectin
Polymorphisms
Diabetes mellitus
Type 1
Thyroiditis
Autoimmune
Celiac disease
 
DeCS
Adolescente
Doenças Auto- Imunes / complicações
Doenças Autoimunes / epidemiologia
Doenças Auto- Imunes / genética
Brasil / epidemiologia
Criança
Criança, pré-escolar
Diabetes Mellitus Tipo 1 / complicações
Diabetes Mellitus, tipo 1 / epidemiologia
Diabetes Mellitus, tipo 1 / genética
Fêmea
Predisposição Genética para Doença
Humanos
Infantil
Masculino
Manose - Encadernação Lectina / genética
Polimorfismo de Nucleotídeo Único
Padrões de referência
 
Citation
ARAUJO, Jacqueline et al. Mannose Binding Lectin Gene Polymorphisms and Associated Auto-Immune Diseases in Type 1 Diabetes Brazilian Patients. Clinical Immunology (Orlando, Fla.), v. 131, n. 2, p. 254–259, maio 2009.
DOI
10.1016/j.clim.2008.12.010
ISSN
1521-7035