Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28017
Title: Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age
Authors: Cooper, Philip J.
Chico, Martha E.
Vaca, Maritza G.
Sandoval, Carlos A.
Loor, Sofia
Amorim, Leila Denise Alves Ferreira
Rodrigues, Laura Cunha
Barreto, Maurício Lima
Strachan, David P.
Affilliation: Universidad Internacional del Ecuador. Facultad de Ciencias Medicas de la Salud y la Vida. Quito, Ecuador / Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador / Institute of Infection and Immunity. London, United Kingdom.
Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, United Kingdom.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
St. George’s University of London. Population Health Research Institute. London, United Kingdom.
Abstract: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. Objectives: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. Methods: A cohort of 2,404 neonates was followed to 5 years of age in a rural district in coastal Ecuador. Data on wheeze were collected by questionnaire and atopy was measured by allergen skin prick test reactivity to 10 allergens at 5 years. Stool samples from mothers and children were examined for geohelminths by microscopy. Measurements and Main Results: A total of 2,090 (86.9%) children were evaluated at 5 years. Geohelminths were observed in 45.5% of mothers and in 34.1% of children by 3 years. Wheeze and asthma were reported for 12.6% and 5.7% of children, respectively, whereas 14.0% had skin test reactivity at 5 years. Maternal geohelminths were associated with an increased risk of wheeze (adjusted odds ratio, 1.41; 95% confidence interval, 1.06–1.88), whereas childhood geohelminths over the first 3 years of life were associated with reduced risk of wheeze (adjusted odds ratio, 0.70; 95% confidence interval, 0.52–0.96) and asthma (adjusted odds ratio, 0.60; 95% confidence interval, 0.38–0.94) but not skin prick test reactivity. The effects on wheeze/asthma were greatest with later age of first infection, were observed only in skin test–negative children, but were not associated with parasite burden or specific geohelminths. Conclusions: Although maternal exposures to geohelminths may increase childhood wheeze, childhood geohelminths during the first 3 years may provide protection through a nonallergic mechanism. Registered as an observational study (ISRCTN41239086).
Keywords: Geohelminths
Atopy
Wheeze
Asthma
Childhood
keywords: Geohelmintos
Atopia
Chiado
Asma
Infância
Issue Date: 2018
Publisher: American Thoracic Society
Citation: COOPER, Philip J. et al. Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age. American Journal of Respiratory and Critical Care Medicine, v. 197, n. 3, p. 364-372, 2018.
Description: Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
DOI: 10.1164/rccm.201706-1222OC
ISSN: 1073-449X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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