Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28147
Title: Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
Authors: Lima, Louise Correia
Queiroz, Gerson de Almeida
Costa, Ryan dos Santos
Neves, Neuza Maria Alcantara
Marques, Cíntia Rodrigues
Costa, Gustavo Nunes de Oliveira
Barreto, Maurício Lima
Figueiredo, Camila Alexandrina Viana
Carneiro, Valdirene Leão
Affilliation: Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto Multidisciplinar em Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasil.
Abstract: Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA. The aim of this work was to identify genetic variants in RORA associated with asthma phenotypes and allergy markers. Genomic DNA samples of 1246 individuals participating from Social Changes Asthma and Allergy in Latin America Program (SCAALA) have been genotyped using Illumina Human 2.5 Omni Beadchip. Logistics regressions have been performed to analyze the association among RORA variants and asthma, skin prick tests (SPT), specific IgE and type 2 cytokine production. Twelve single nucleotide variants (SNVs) were significantly associated with atopy (P < 0.01), in which four of them, rs10162630, rs17191519, rs17270243, and rs55796775 and their haplotypes were strongly and positively associated (P < 0.001). Furthermore, these variants increased the RORA gene expression in silico analysis. Other SNVs in RORA were associated with allergy markers, atopic and non-atopic asthma. Therefore, it is believed that variants in RORA gene may influence immunologic features of asthma and allergies and could be possible targets for future treatment of allergic diseases.
Keywords: Polymorphism
Atopic sensitization
RORA
Asthma
keywords: Polimorfismo
Sensibilização atópica
RORA
Asma
Issue Date: 2019
Publisher: Elsevier
Citation: LIMA, Louise Correia et al. Genetic variants in RORA are associated with asthma and allergy markers in an admixed population. Cytokine, v. 113, p. 177-184, 2019.
Description: Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
O artigo encontra-se disponível em acesso aberto para download no site do Editor.
DOI: 10.1016/j.cyto.2018.07.004
ISSN: 1043-4666
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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