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NEUROPILINS, SEMAPHORINS, AND THEIR ROLE IN THYMOCYTE DEVELOPMENT
Cruz, Daniella Arêas Mendes da et al. | Date Issued: 2009
Author
Cruz, Daniella Arêas Mendes da
Lepelletier, Yves
Brignier, Anne C.
Smaniotto, Salete
Renand, Amédée
Milpied, Pierre
Dardenne, Mireille
Hermine, Olivier
Savino, Wilson
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil / Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Universidade Federal de Alagoas. Instituto de Ciências Biomédicas e da Saúde. Maceió, AL, Brasil.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France.
Paris Descartes University. Centre National de la Recherche Scientifique. Unité Mixte de Recherche. Necker Hospital. Paris, France / Hôspitaux de Paris. Assistance Publique. Paris, France / Universidade Federal de Alagoas. Instituto de Ciências Biomédicas e da Saúde. Maceió, AL, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Abstract
Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.
Keywords in Portuguese
Semaforinas
Neuropilinas
Timo
migração de timócitos
desenvolvimento de timócitos
 
Keywords
semaphorins
neuropilins
thymus
thymocyte migration
thymocyte development
 
Publisher
Karger Publishers
Citation
CRUZ, Daniela Arêas Mnedes da; et al. Neuropilins, Semaphorins, and Their Role in Thymocyte Development. Neuroimmunomodulation: Ann. N.Y. Acad. Sci, v.1153, p. 20–28, 2009.
DOI
10.1111/j.1749-6632.2008.03980.x
ISSN
1021-7401