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2030-01-01
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TARGETING CASPASES IN INTRACELLULAR PROTOZOAN INFECTIONS
Guillermo, Landi V. C. et al. | Date Issued: 2009
Author
Guillermo, Landi V. C.
Pereira, Wânia F.
Meis, Juliana de
Gomes, Flavia L. Ribeiro
Silva, Elisabeth M.
Palhares, Karina Kroll
Takiya, Christina M.
Lopes, Marcela F
Affilliation
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
Abstract
Caspases are cysteine aspartases acting either as initiators (caspases 8, 9, and 10) or executioners (caspases 3, 6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span by targeting caspase activation. Conversely, caspase activation, followed by apoptosis of lymphocytes and other cells, prevents effective immune responses to chronic parasite infection. Here we discuss how pharmacological inhibition of caspases might affect the immunity to protozoan infections, by either blocking or delaying apoptosis.
Keywords in Portuguese
Trypanosoma cruzi
Apoptose
Imunidade
Parasitos
 
Keywords
Apoptosis
caspase
immunity
parasite
Trypanosoma cruzi
 
Publisher
Taylor & Francis
Citation
GUILLERMO, Landi V. C. et al. Targeting caspases in intracellular protozoan infections. Immunopharmacology and Immunotoxicology, v.31, n.2, p.159–173, 2009.
DOI
10.1080/08923970802332164
ISSN
0892-3973