Author | Gama, Bianca Ervatti | |
Author | Oliveira, Natália Ketrin Almeida de | |
Author | Souza, José Maria de | |
Author | Daniel-Ribeiro, Cláudio Tadeu | |
Author | Cruz, Maria de Fátima Ferreira da | |
Access date | 2018-08-23T12:14:11Z | |
Available date | 2018-08-23T12:14:11Z | |
Document date | 2009 | |
Citation | GAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28309 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium vivax | pt_BR |
Subject in Portuguese | Malária | pt_BR |
Subject in Portuguese | quimiorresistência | pt_BR |
Title | Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates | pt_BR |
Type | Article | pt_BR |
Abstract | Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | malaria | pt_BR |
Subject | chemoresistance | pt_BR |
Subject | pvmdr1 | pt_BR |
Subject | pvdhfr | pt_BR |
e-ISSN | 1678-8060 | |