Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28309
Title: Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
Authors: Gama, Bianca Ervatti
Oliveira, Natália Ketrin Almeida de
Souza, José Maria de
Daniel-Ribeiro, Cláudio Tadeu
Cruz, Maria de Fátima Ferreira da
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Instituto Evandro Chagas. Secretaria de Vigilância em Saúde. Ensaios Clínicos Ambulatoriais e Laboratoriais de Malária. Belém, PA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Abstract: Plasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.
Keywords: Plasmodium vivax
malaria
chemoresistance
pvmdr1
pvdhfr
keywords: Plasmodium vivax
Malária
quimiorresistência
Issue Date: 2009
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: GAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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