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NATURALLY ACQUIRED HUMORAL AND CELLULAR IMMUNE RESPONSES TO PLASMODIUM VIVAX MEROZOITE SURFACE PROTEIN 9 IN NORTHWESTERN AMAZON INDIVIDUALS
Lima Junior, J. C. et al. | Date Issued: 2008
Author
Lima Junior, J. C.
Tran, T. M.
Meyer, E. V. S.
Singh, B.
De Simone, Salvatore Giovanni
Santos, F.
Daniel-Ribeiro, Cláudio Tadeu
Moreno, A.
Barnwell, J. W.
Galinski, M. R.
Ferreira, J. Oliveira
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Proteínas e Peptídeos. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Bioquímica e Biologia Molecular. Niterói, RJ, Brasil.
Laboratório Central de Saúde Pública de Rondônia. Departamento de Entomologia. Porto Velho, RO, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University School of Medicine. Divisiond of Infectious Disease. Atlanta, GA, USA.
Center for Disease Control and Prevention. Division of Parasitic Diseases. Atlanta, GA, USA.
Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University School of Medicine. Divisiond of Infectious Disease. Atlanta, GA, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.
Abstract
Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied.
Keywords in Portuguese
Plasmodium vivax
Malária
Vacinas
Noroeste da Amazônia
 
Keywords
Plasmodium vivax
Mal
Vaccine
Merozoite Surface Protein-9
Northwestern Amazon
 
Publisher
Elsevier 12 Months
Citation
LIMA JUNIOR, J. C. et al. Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals. Vaccine, v. 26, n. 51, p. 6645-6654, Dec. 2008.
DOI
10.1016/j.vaccine.2008.09.029
ISSN
0264-410X