Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/28374
Title: Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae
Authors: Silva, Tatiana Pereira da
Silva, Ana Caroline Costa da
Baruque, Maria da Graça Araújo
Oliveira, Rosane Barbosa de
Machado, Marcelo Pelajo
Sarno, Euzenir Nunes
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.
Abstract: Nerve damage, a characteristic of leprosy, is the cause of patient deformities and a consequence of Schwann cells (SC) infection by Mycobacterium leprae. Although function/dysfunction of SC in human diseases like leprosy is difficult to study, many in vitro models, including SC lines derived from rat and/or human Schwannomas, have been employed. ST88-14 is one of the cell lineages used by many researchers as a model for M. leprae/SC interaction. However, it is necessary to establish the values and limitations of the generated data on the effects of M. leprae in these SC. After evaluating the cell line phenotype in the present study, it is close to non-myelinating SC, making this lineage an ideal model for M. leprae/SC interaction. It was also observed that both M. leprae and PGL-1, a mycobacterial cell-wall component, induced low levels of apoptosis in ST88-14 by a mechanism independent of Bcl-2 family members.
Keywords: Schwann cell
Mycobacterium leprae
apoptosis
Leprosy
keywords: Mycobacterium leprae
Apoptose
Células de Schwann
Hanseníase
Issue Date: 2008
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: SILVA, Tatiana Pereira da; et al. Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae. Mem Inst Oswaldo Cruz, v.103, n.4, p.363-369, June 2008.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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