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AGE-RELATED COGNITIVE IMPAIRMENT IS ASSOCIATED WITH LONG-TERM NEUROINFLAMMATION AND OXIDATIVE STRESS IN A MOUSE MODEL OF EPISODIC SYSTEMIC INFLAMMATION
d`Avila, Joana Costa et al. | Date Issued: 2018
Author
d`Avila, Joana Costa
Siqueira, Luciana Domett
Mazeraud, Aurélien
Azevedo, Estefania Pereira
Foguel, Debora
Faria Neto, Hugo Caire Castro
Sharshar, Tarek
Chrétien, Fabrice
Bozza, Fernando Augusto
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Pasteur Institute. Human Histopathology and Animal Models. Paris, France.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.
Pasteur Institute. Human Histopathology and Animal Models. Paris, France.
Pasteur Institute. Human Histopathology and Animal Models. Paris, France.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto IDÓR de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.
Abstract
Background: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechanisms involved in age-related cognitive decline associated to episodic systemic inflammation are not completely understood. The aim of this study was to identify neuropathological features associated to age-related cognitive decline in a mouse model of episodic systemic inflammation.
Keywords in Portuguese
Neuroinflamação
Estresse Oxidativo
comprometimento cognitivo relacionado à idade
inflamação sistêmica episódica
 
Keywords
Neuroinflammation
Oxidative stress
episodic systemic inflammation
Age-related cognitive impairment
 
Publisher
BioMed Central
Citation
d`AVILA, Joana Costa et al. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. Journal of Neuroinflammation, v. 15, n. 28, p. 1-13, 2018.
DOI
10.1186/s12974-018-1059-y
ISSN
1742-2094