| Author | Jardim, Guilherme A. M. | |
| Author | Oliveira, Willian X. C. | |
| Author | Freitas, Rossimiriam P. de | |
| Author | Menna-Barreto, Rubem F. S. | |
| Author | Silva, Thaissa L. | |
| Author | Goulart, Marilia O. F. | |
| Author | Silva Júnior, Eufrânio N. da | |
| Access date | 2018-09-13T12:04:11Z | |
| Available date | 2018-09-13T12:04:11Z | |
| Document date | 2018 | |
| Citation | JARDIM, Guilherme A. M. et al. Direct sequential C–H iodination/organoylthiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones. Org. Biomol. Chem., v.16, p.1686-1691, 2018. | pt_BR |
| ISSN | 1477-0520 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/28719 | |
| Language | eng | pt_BR |
| Publisher | Royal Society of Chemistry | pt_BR |
| Rights | restricted access | |
| Subject in Portuguese | Química | pt_BR |
| Subject in Portuguese | quinonas tripanocidas potentes | pt_BR |
| Subject in Portuguese | novo protocolo | pt_BR |
| Subject in Portuguese | sistemas naftoquinoidais | pt_BR |
| Subject in Portuguese | química de quinona | pt_BR |
| Title | Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones | pt_BR |
| Type | Article | |
| DOI | 10.1039/c8ob00196k | |
| Abstract | We report a sequential C-H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Alagoas. Instituto de Química e Biotecnologia. Maceió, AL, Brasil. | pt_BR |
| Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, Brasil. | pt_BR |
| Subject | Chemistry | pt_BR |
| Subject | new protocol | pt_BR |
| Subject | potent trypanocidal quinones | pt_BR |
| Subject | naphthoquinoidal systems | pt_BR |
| Subject | quinone chemistry | pt_BR |
| e-ISSN | 1477-0539 | |
| Embargo date | 2030-01-01 | |
